Pine D S, Wasserman G A, Coplan J, Fried J A, Huang Y Y, Kassir S, Greenhill L, Shaffer D, Parsons B
Department of Child and Adolescent Psychiatry, College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA.
Am J Psychiatry. 1996 Apr;153(4):538-44. doi: 10.1176/ajp.153.4.538.
This study examined the cross-sectional association between platelet membrane serotonin 2A (5-HT2A) receptor variables in children and characteristics of their parents that place these children at risk for antisocial behavior.
As part of a larger prospective study investigating predictors of antisocial behavior, 38 younger brothers of convicted delinquents provided platelet samples; samples from 34 boys (mean age=8.3 years) were usable. The authors determined the density (Bmax) and affinity (Kd) of platelet membrane 5-HT2A receptors by using [3H]lysergic acid diethylamide. They also measured parental characteristics related to serotonergic dysfunction in prior studies, the quality of parent-child interactions, and psychiatric profiles of the boys who provided platelets.
Bmax was significantly lower in boys whose parents had histories of substance abuse or incarceration. Bmax was also inversely related to harsh parenting; boys raised in environments characterized by frequent parental physical punishment and anger had a significantly lower Bmax. Bmax was not related to boys' disruptive behavior.
In boys at risk for antisocial behavior, the density of 5-HT2A receptors on platelets is inversely related to parental factors known to place youth at risk for antisocial behavior.
本研究探讨了儿童血小板膜5-羟色胺2A（5-HT2A）受体变量与使其有反社会行为风险的父母特征之间的横断面关联。
作为一项调查反社会行为预测因素的大型前瞻性研究的一部分，38名已定罪少年犯的弟弟提供了血小板样本；34名男孩（平均年龄=8.3岁）的样本可用。作者使用[3H]麦角酸二乙酰胺测定血小板膜5-HT2A受体的密度（Bmax）和亲和力（Kd）。他们还测量了先前研究中与血清素功能障碍相关的父母特征、亲子互动质量以及提供血小板的男孩的精神状况。
父母有药物滥用或监禁史的男孩的Bmax显著较低。Bmax也与严厉的养育方式呈负相关；在以父母频繁体罚和愤怒为特征的环境中长大的男孩的Bmax显著较低。Bmax与男孩的破坏性行为无关。
在有反社会行为风险的男孩中，血小板上5-HT2A受体的密度与已知会使青少年有反社会行为风险的父母因素呈负相关。
