Skobieranda K, Helm K F
Department of Medicine, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey 17033, USA.
Am J Dermatopathol. 1995 Oct;17(5):471-5. doi: 10.1097/00000372-199510000-00007.
Morphea is an idiopathic disorder the hallmark of which is fibrosis of the skin. The regulatory factors resulting in the increased collagen production have not been determined. Within the dermis there are dendritic cells with possible immunological functions that express either the human progenitor cell antigen (CD34) or factor XIIIa. Immunohistochemical stains for factor XIIIa, CD34, S100, proliferating nuclear cell antigen, and vimentin were performed on 26 skin biopsies from patients with morphea and 11 biopsies from normal skin. A decreased number of CD34-expressing cells was seen in the affected skin from morphea patients, while there was an increased number of cells expressing factor XIIIa and vimentin. We hypothesize that CD34-positive dendritic cells may have a regulatory role in collagen synthesis and that lack of CD34 expression can be used as a marker for morphea.
硬斑病是一种特发性疾病，其标志是皮肤纤维化。导致胶原蛋白生成增加的调节因子尚未确定。真皮内存在具有可能免疫功能的树突状细胞，这些细胞表达人类祖细胞抗原（CD34）或因子XIIIa。对26例硬斑病患者的皮肤活检标本和11例正常皮肤活检标本进行了因子XIIIa、CD34、S100、增殖细胞核抗原和波形蛋白的免疫组织化学染色。在硬斑病患者的受累皮肤中，表达CD34的细胞数量减少，而表达因子XIIIa和波形蛋白的细胞数量增加。我们推测，CD34阳性树突状细胞可能在胶原蛋白合成中具有调节作用，并且缺乏CD34表达可作为硬斑病的一个标志物。
