Wang S J, Fuh J L, Teng E L, Liu C Y, Lin K P, Chen H M, Lin C H, Wang P N, Ting Y C, Wang H C, Lin K N, Chou P, Larson E B, Liu H C
Neurological Institute, Veterans General Hospital-Taipei, Taiwan.
Arch Neurol. 1996 Jan;53(1):66-71. doi: 10.1001/archneur.1996.00550010084020.
Most published studies have shown lower prevalence rates of Parkinson's disease (PD) in Asian and black African than in Western countries, leading to the hypothesis that Asians and blacks might be protected from PD.
To investigate the prevalence of PD in a Chinese population.
Community-based survey.
Registered residents 50 years of age or older (N = 5061) on the islet of Kinmen located off the southeastern coast of China [corrected].
Single-phase door-to-door survey by neurologists. All participants were administered a questionnaire and received motor examinations of the Unified Parkinson's Disease Rating Scale.
The participation rate was 96% (N = 3915) among 4158 contacted individuals. Twenty-three cases of PD were identified, including three cases with dementia. The crude prevalence rate of PD was 587 (95% confidence interval (CI), 373 to 884) per 100,000 persons 50 years of age or older. Assuming no case of PD among individuals under 50 years of age, the prevalence rate was 119 (95% CI, 80 to 169) per 100,000 for the total population.
The prevalence rates of PD in Kinmen were much higher than those reported from mainland China, but slightly lower than those reported from more developed countries. The present findings suggest that, instead of genetic factors, differences in case-ascertainment, life expectancy, and the length of survival with PD may be more important contributors to the variations in observed PD prevalence rates.
大多数已发表的研究表明，亚洲人和非洲黑人中帕金森病（PD）的患病率低于西方国家，这导致了一种假设，即亚洲人和黑人可能对PD具有抵抗力。
调查中国人群中PD的患病率。
基于社区的调查。
中国东南沿海金门岛50岁及以上的登记居民（N = 5061）[已校正]。
由神经科医生进行单相逐户调查。所有参与者都接受了问卷调查，并接受了统一帕金森病评定量表的运动检查。
在4158名被联系的个体中，参与率为96%（N = 3915）。共识别出23例PD病例，其中3例伴有痴呆。50岁及以上人群中PD的粗患病率为每10万人587例（95%置信区间（CI），373至884）。假设50岁以下个体中无PD病例，总人口的患病率为每10万人119例（95%CI，80至169）。
金门岛PD的患病率远高于中国大陆报道的患病率，但略低于较发达国家报道的患病率。目前的研究结果表明，与遗传因素相比，病例确诊、预期寿命以及PD存活时间的差异可能是观察到的PD患病率差异更重要的因素。
