术前放疗和化疗对口腔鳞状细胞癌中核仁组成区嗜银蛋白计数的影响。

Effects of preoperative radiation and chemotherapy on AgNOR counts in oral squamous cell carcinoma.

作者信息

Kinoshita Y, Dohi M, Mizutani N, Ikeda A

机构信息

Department of Oral Surgery, Kanagawa Dental College, Yokosuka, Japan.

出版信息

J Oral Maxillofac Surg. 1996 Mar;54(3):304-7; discussion 307-8. doi: 10.1016/s0278-2391(96)90748-x.

DOI:10.1016/s0278-2391(96)90748-x

PMID:8600237

Abstract

PURPOSE

This study evaluated the relationship between argyophilic nucleolar organizer regions (AgNORs) and the histologic effects of preoperative chemotherapy or external radiation on oral squamous cell carcinoma.

PATIENTS AND METHODS

Thirty-three cases of oral squamous cell carcinoma that were treated with chemotherapy (pepleomycin or 5-FU) or 60Co external radiation were studied. Biopsies were done on the tumor sites before therapy and the number of AgNORs per nucleus was recorded. After therapy, the tumors were resected and the therapeutic effects were assessed histologically.

RESULTS

The number of AgNORs per nucleus before therapy ranged from 4.7 to 12.45 (mean +/- SD, 8.71 +/- 2.26). As the number of AgNORs per nucleus increased, the histological effects of preoperative therapy were enhanced. It was 5.75 +/- 0.77 in cases with a poor histological effect of preoperative treatment, 8.03 +/- 1.85 in cases with a mild histological effect, 9.09 +/- 1.85 in the moderate histological effect group, and 10.46 +/- 1.56 in the excellent histological effect group.

CONCLUSION

These results suggest that AgNORs could be used to predict the effects of preoperative radiation and chemotherapy on oral squamous cell carcinoma.

摘要

目的

本研究评估了嗜银核仁组成区（AgNORs）与术前化疗或外照射对口腔鳞状细胞癌的组织学影响之间的关系。

患者与方法

研究了33例接受化疗（平阳霉素或5-氟尿嘧啶）或60钴外照射治疗的口腔鳞状细胞癌患者。在治疗前对肿瘤部位进行活检，并记录每个细胞核中AgNORs的数量。治疗后，切除肿瘤并进行组织学疗效评估。

结果

治疗前每个细胞核中AgNORs的数量范围为4.7至12.45（平均值±标准差，8.71±2.26）。随着每个细胞核中AgNORs数量的增加，术前治疗的组织学效果增强。术前治疗组织学效果差的病例为5.75±0.77，轻度组织学效果的病例为8.03±1.85，中度组织学效果组为9.09±1.85，优秀组织学效果组为10.46±1.56。