Sano K, Takahashi H, Fujita S, Inokuchi T, Pe M B, Okabe H, Tsuda N
Second Department of Oral and Maxillofacial Surgery, Nagasaki University School of Dentistry, Japan.
J Oral Pathol Med. 1991 Feb;20(2):53-6. doi: 10.1111/j.1600-0714.1991.tb00889.x.
Silver-binding nucleolar organizer regions (AgNORs) were counted in sections from formalin-fixed, paraffin-embedded tissue blocks of oral squamous cell carcinoma. Thirty-nine cases, that comprised poor prognostic group (n = 19) and good prognostic group (n = 20), were examined with respect to the relation between AgNOR counts and histologic grading, and correlation between AgNOR counts and prognosis. The pooled mean AgNOR counts were: Grade 1 carcinomas, 6.39 +/- 1.67 (mean +/- SD; n = 35); Grade 2, 9.74 +/- 1.72 (n = 3). Mean AgNOR count of Grade 3 was 6.19 +/- 2.37 (n = 1). The pooled mean AgNOR count in poor prognostic group was higher than that in good prognostic group. Five-year survival rate of the cases with high AgNOR counts (greater than or equal to 6.5) was significantly lower than that with low AgNOR counts (less than 6.5). High AgNOR counts are highly suggestive of poor prognosis in oral squamous cell carcinoma.
对福尔马林固定、石蜡包埋的口腔鳞状细胞癌组织块切片中的银结合核仁组成区（AgNORs）进行计数。针对39例患者（其中包括预后较差组，n = 19；预后较好组，n = 20），研究了AgNOR计数与组织学分级之间的关系，以及AgNOR计数与预后之间的相关性。汇总后的平均AgNOR计数为：1级癌，6.39 ± 1.67（平均值 ± 标准差；n = 35）；2级，9.74 ± 1.72（n = 3）。3级的平均AgNOR计数为6.19 ± 2.37（n = 1）。预后较差组的汇总平均AgNOR计数高于预后较好组。AgNOR计数高（大于或等于6.5）的病例的5年生存率显著低于AgNOR计数低（小于6.5）的病例。AgNOR计数高强烈提示口腔鳞状细胞癌预后不良。
