Nevalainen T J, Kallajoki M, Pesonen E, Andersson S, Kärkkäinen P, Höckerstedt K
Department of Pathology, University of Turku, Finland.
Lab Invest. 1996 Mar;74(3):585-91.
The concentration of group II phospholipase A2 was measured in blood plasma samples before and after liver transplantation in a 27-year-old woman who suffered from a massive epitheloid hemangioendothelioma of the liver. The pretransplantation concentration of group II phospholipase A2 was 830 microg/L, which is markedly above the upper limit of the reference interval (10.8 microg/L). After the transplantation, there was a dramatic decrease in the group II phospholipase A2 level (33 microg/L on the first posttransplantation day). In situ hybridization of mRNA and immunohistochemistry revealed synthesis of group II phospholipase A2 in hepatocytes in non-neoplastic areas of the liver. Tumor cells did not contain group II phospholipase A2. The results indicate that group II phospholipase A2 circulating in blood plasma originates in hepatocytes.
对一名患有肝脏巨大上皮样血管内皮瘤的27岁女性，在肝移植前后的血浆样本中测量了II型磷脂酶A2的浓度。移植前II型磷脂酶A2的浓度为830微克/升，明显高于参考区间的上限（10.8微克/升）。移植后，II型磷脂酶A2水平急剧下降（移植后第一天为33微克/升）。mRNA的原位杂交和免疫组织化学显示，在肝脏非肿瘤区域的肝细胞中合成了II型磷脂酶A2。肿瘤细胞不含II型磷脂酶A2。结果表明，血浆中循环的II型磷脂酶A2起源于肝细胞。
