Leonard A, Craft A W, Moss C, Malcolm A J
Department of Child Health, University of Newcastle upon Tyne, UK.
Med Pediatr Oncol. 1996 Apr;26(4):249-53. doi: 10.1002/(SICI)1096-911X(199604)26:4<249::AID-MPO5>3.0.CO;2-J.
Two children who had the Rothmund-Thomson syndrome and developed osteosarcoma are reported. The 10 previously reported cases are reviewed. The osteosarcomas developed at a younger age than normally expected and 66% occurred in the tibia/fibula. Four of the five patients for whom information was available showed undue sensitivity to cancer chemotherapy agents with prolonged myelosuppression and severe mucositis. It is recommended that doxorubicin in particular should be given with extreme caution in such patients.
报告了两名患有罗思蒙德-汤姆森综合征并发生骨肉瘤的儿童。对之前报告的10例病例进行了回顾。骨肉瘤的发病年龄比正常预期的要小，66%发生在胫骨/腓骨。在有信息可查的5名患者中，有4名对癌症化疗药物表现出过度敏感，伴有骨髓抑制延长和严重的粘膜炎。建议对此类患者使用阿霉素时应格外谨慎。
