Activity of iPMS and nPMS in mouse bone marrow micronucleus assays: comparison with mouse dominant lethal assay data.
作者信息
Adler I D, Tinwell H, Kliesch U, Ashby J
机构信息
GSF-Institut fur Saugetiergenetik, Neuherberg, D-85758 Oberschleissheim, Germany.
出版信息
Mutat Res. 1996 Feb 1;349(2):241-7. doi: 10.1016/0027-5107(95)00188-3.
PMID:8600355
Abstract
isoPropyl methanesulphonate (iPMS) and its n-propyl analogue (nPMS) are shown to be active in mouse bone marrow micronucleus assays using male CBA, male and female (C3H/El X 102/E1)Fl and male and female Muta Mouse mice. iPMS was significantly more active than nPMS. No significant strain or gender differences were observed. These findings reflect the differences reported earlier for these two chemicals in mouse dominant lethal mutation assays. The earlier described dominant lethal assay data are represented schematically and discussed.
摘要
Zotero 插件