Ravindran A V, Griffiths J, Merali Z, Anisman H
Department of Psychiatry, University of Ottawa, Ontario, Canada.
Psychosom Med. 1995 Nov-Dec;57(6):555-63. doi: 10.1097/00006842-199511000-00008.
Major depression and dysthymia (chronic, low grade depression) were associated with an increase in the number of CD16/56 (natural killer; NK) cells in blood, whereas other lymphocyte subsets (CD3, CD4, CD8, CD19, and the CD4/CD8 ratio) did not differ from control subjects. After treatment with a specific serotonin reuptake inhibitor, the symptoms of depression were alleviated in both the major depressive and dysthymic patients. Likewise, NK cell numbers declined to control values in these treated groups. Among the major depressive patients, the NK cell number reached control values within 4 weeks, whereas 6 months of treatment was required for such an effect to be achieved in the dysthymic patients. Although plasma levels of epinephrine, norepinephrine, cortisol, and ACTH were not different between groups, among the major depressive patients ACTH was inversely correlated with total lymphocytes, CD3, and CD19, and epinephrine was directly related to the CD4 and CD4/CD8 ratio. Among dysthymics, ACTH was unrelated to any of the lymphocyte subsets, but norepinephrine was directly related to total lymphocytes, CD3, CD4, and NK cells. The data are interpreted in terms of stress perception among major depressive and dysthymic patients and the potential impact of stressor experiences on immune processes.
重度抑郁症和心境恶劣（慢性轻度抑郁症）与血液中CD16/56（自然杀伤细胞；NK细胞）数量增加有关，而其他淋巴细胞亚群（CD3、CD4、CD8、CD19以及CD4/CD8比值）与对照组无差异。在使用特异性5-羟色胺再摄取抑制剂治疗后，重度抑郁和心境恶劣患者的抑郁症状均得到缓解。同样，这些治疗组中的NK细胞数量降至对照值。在重度抑郁患者中，NK细胞数量在4周内达到对照值，而心境恶劣患者则需要6个月的治疗才能达到这种效果。尽管各组间肾上腺素、去甲肾上腺素、皮质醇和促肾上腺皮质激素的血浆水平无差异，但在重度抑郁患者中，促肾上腺皮质激素与总淋巴细胞、CD3和CD19呈负相关，肾上腺素与CD4和CD4/CD8比值呈正相关。在心境恶劣患者中，促肾上腺皮质激素与任何淋巴细胞亚群均无关联，但去甲肾上腺素与总淋巴细胞、CD3、CD4和NK细胞呈正相关。这些数据是根据重度抑郁和心境恶劣患者的应激感知以及应激源经历对免疫过程的潜在影响来解释的。
