Ravindran A V, Griffiths J, Merali Z, Anisman H
Department of Psychiatry, University of Ottawa, Canada.
Psychoneuroendocrinology. 1996 Nov;21(8):659-71. doi: 10.1016/s0306-4530(96)00030-3.
Major depression and dysthymia have been associated with increased perception of day-to-day stressors, greater reliance on emotion-focused coping efforts, and reduced perception of uplifting events. Moreover, it has been observed that levels of circulating natural killer (NK) cells were elevated in depressed patients. Given that mild stressors may increase circulating NK cells, it is conceivable that the elevated NK cells in depression may be secondary to the increased stress perception associated with the illness. In the present investigation a laboratory stressor, comprising a mathematical challenge, increased circulating NK cells; however, the extent of the increase was comparable in depressive, dysthymic and control subjects. Moreover, the increased NK cells induced by the stressor procedure appeared to be independent of variations of plasma cortisol, ACTH or norepinephrine. Interestingly, although the NK changes were not differentially influenced by stressors in the subject populations, in the major depressive patients correspondence existed between NK cell levels and emotion-focused coping styles. Likewise, the response to a laboratory stressor was directly related to the severity of depression and to the use of coping styles involving cognitive restructuring or problem solving.
重度抑郁症和心境恶劣障碍与对日常应激源的感知增加、对以情绪为中心的应对方式的更大依赖以及对令人振奋事件的感知减少有关。此外，据观察，抑郁症患者循环自然杀伤（NK）细胞水平升高。鉴于轻度应激源可能会增加循环NK细胞，因此可以推测抑郁症中NK细胞升高可能继发于与该疾病相关的应激感知增加。在本研究中，一项包括数学挑战的实验室应激源增加了循环NK细胞；然而，抑郁、心境恶劣和对照受试者的增加程度相当。此外，应激源程序诱导的NK细胞增加似乎与血浆皮质醇、促肾上腺皮质激素或去甲肾上腺素的变化无关。有趣的是，尽管NK变化在不同受试者群体中不受应激源的差异影响，但在重度抑郁症患者中，NK细胞水平与以情绪为中心的应对方式之间存在对应关系。同样，对实验室应激源的反应与抑郁症的严重程度以及涉及认知重构或问题解决的应对方式的使用直接相关。
