Strouse T B, Fairbanks L A, Skotzko C E, Fawzy F I
University of California at Los Angeles, Department of Psychiatry and Biobehavioral Sciences 90024, USA.
Psychosomatics. 1996 Jan-Feb;37(1):23-30. doi: 10.1016/S0033-3182(96)71594-3.
Depression and anxiety disorders are common clinical problems in organ transplant recipients, but there is a paucity of clinical data to inform the selection of psychopharmacologic treatment. The authors retrospectively compared 13 depressed organ transplant recipients treated with fluoxetine with 13 nondepressed matched control recipients and 11 transplant recipients treated with tricyclic antidepressants (nortriptyline or desipramine). Blood level:dose ratios and dose-response relationships for cyclosporine were virtually identical in all three groups before and during treatment. No increase in adverse clinical events was detected in either active treatment group compared with the control subjects. Fluoxetine appeared to be well tolerated by this population of transplant patients, and the authors failed to detect significant alterations in cyclosporine levels or graft function.
抑郁和焦虑症是器官移植受者常见的临床问题，但用于指导精神药物治疗选择的临床数据却很匮乏。作者回顾性地比较了13例接受氟西汀治疗的抑郁器官移植受者、13例与之匹配的非抑郁对照受者以及11例接受三环类抗抑郁药（去甲替林或地昔帕明）治疗的移植受者。治疗前及治疗期间，三组中环孢素的血药浓度与剂量之比及剂量-反应关系几乎相同。与对照组相比，两个积极治疗组均未检测到不良临床事件增加。氟西汀似乎在这群移植患者中耐受性良好，作者未检测到环孢素水平或移植功能有显著改变。
