Champlin R E
Division of Medicine, Department of Hematology, Section of Blood and Marrow Transplantation, University of Texas M.D. Anderson Cancer Center, Houston, USA.
Semin Oncol. 1996 Apr;23(2 Suppl 4):15-21.
Peripheral blood progenitor cells (PBPCs) are an effective source of hematopoietic stem cells for autologous or allogeneic transplantation. Progenitors must be mobilized into the circulation to allow efficient collection. Some promising mobilizing regimens include the use of stem cell factor and growth factors such as interleukin-3, granulocyte colony-stimulating factor, and granulocyte-macrophage colony-stimulating factor. Transplantation of PBPCs has several advantages over bone marrow transplantation: larger numbers of progenitors can be collected, general anesthesia and multiple bone marrow aspirations can be avoided, and hematologic recovery appears to be more rapid and predictable with PBPCs. The disadvantages of using PBPCs for transplantation include the costs of multiple aphereses and purging procedures, the requirement for a mobilizing regimen, and the necessity for vascular access. Several uncertainties remain regarding the transplantation of PBPCs, including the optimal dose and composition of cells for transplantation.
外周血祖细胞（PBPCs）是自体或异体移植中造血干细胞的有效来源。祖细胞必须被动员到循环系统中以便有效采集。一些有前景的动员方案包括使用干细胞因子和生长因子，如白细胞介素-3、粒细胞集落刺激因子和粒细胞-巨噬细胞集落刺激因子。与骨髓移植相比，外周血祖细胞移植有几个优点：可以采集到更多数量的祖细胞，可避免全身麻醉和多次骨髓穿刺，并且外周血祖细胞的血液学恢复似乎更快且更可预测。使用外周血祖细胞进行移植的缺点包括多次单采和净化程序的费用、对动员方案的要求以及血管通路的必要性。关于外周血祖细胞移植仍存在一些不确定性，包括移植细胞的最佳剂量和组成。
