Drug interactions on body temperature maintenance in the mouse.

Exposure of mice to an environmental temperature leads to a loss of body temperature and death in 5-6 hours. Intraperitoneal injection of water or d-amphetamine exacerbates this effect, while caffeine has a modest antagonistic effect. The combination of caffeine and d-amphetamine is synergistic and leads to a rapid loss in body temperature with death occurring in less than 3 hours.