Adleman L M, Wofsy D
Laboratory for Molecular Science and Department of Computer Science, University of Southern California, Los Angeles, USA.
J Acquir Immune Defic Syndr Hum Retrovirol. 1996 Apr 1;11(4):334-40. doi: 10.1097/00042560-199604010-00003.
Recently, it has been proposed that normal T-cell count is maintained by a homeostatic mechanism which is "blind" to the distinction between CD4+ T cells and CD8+ T cells. Interest in this blind homeostasis hypothesis (BHH) stems in part from its implications regarding the pathogenesis and treatment of HIV infection. In this report, BHH was tested in CD4-deficient mice. We found that as predicted by BHH, despite the absence of CD4+ T cells, CD4-deficient mice maintain normal absolute T-cell counts in the blood and spleen primarily through a marked increase in CD8+ T cells. These findings provide strong new support for BHH.
最近，有人提出正常的T细胞计数是由一种稳态机制维持的，这种机制对CD4⁺ T细胞和CD8⁺ T细胞之间的区别“视而不见”。对这种盲态稳态假说（BHH）的兴趣部分源于其对HIV感染发病机制和治疗的影响。在本报告中，在CD4缺陷小鼠中对BHH进行了测试。我们发现，正如BHH所预测的那样，尽管缺乏CD4⁺ T细胞，但CD4缺陷小鼠主要通过CD8⁺ T细胞的显著增加，维持血液和脾脏中正常的绝对T细胞计数。这些发现为BHH提供了有力的新支持。
