Honda H, Tanemura M, Imayama S
Kanebo Institute for Cancer Research, Tomobuchicho, Miyakojimaku, Osaka, Japan.
J Invest Dermatol. 1996 Feb;106(2):312-5. doi: 10.1111/1523-1747.ep12342964.
The cells of the stratum corneum in the epidermis of some mammalian species are precisely stacked in columns in a honeycomb fashion. The epidermis constantly loses surface cells, which are replaced by basal cells that have differentiated during migration to the surface. The path of this migration is seen as precisely defined columns of cells that are in compressed Kelvin's tetrakaidecahedral form. We present a computer simulation of this architectural organization based on the assumption that the cells that migrate upward occupy less crowded regions. The simulation not only explained the mechanism by which the architecture is maintained during the process of cell replacement, but also showed that the architecture was spontaneously organized from initial cells supplied at random. Living organisms consist of self-organizing systems at various levels; however, self-organizing systems have been investigated mostly at the molecular level. The present computer simulation clarified the self-organizing system at the cellular level.
一些哺乳动物物种表皮中的角质层细胞以蜂窝状精确地排列成柱状。表皮不断失去表层细胞，这些细胞由在向表面迁移过程中分化的基底细胞所取代。这种迁移路径表现为精确排列的呈压缩开尔文十四面体形式的细胞柱。我们基于向上迁移的细胞占据较不拥挤区域这一假设，对这种结构组织进行了计算机模拟。该模拟不仅解释了在细胞更替过程中结构得以维持的机制，还表明这种结构是从随机供应的初始细胞中自发组织形成的。生物体由各级别的自组织系统组成；然而，自组织系统大多是在分子层面进行研究的。目前的计算机模拟阐明了细胞层面的自组织系统。
