Uchida S, Okudaira N, Nishihara K, Iguchi Y
Department of Psychophysiology, Tokyo Institute of Psychiatry, Tokyo, Japan.
Life Sci. 1996;58(10):PL199-205. doi: 10.1016/0024-3205(96)00026-4.
Flunitrazepam (FNZ) (4mg), an intermediate type benzodiazepine (BDZ) hypnotic, was administered orally to five healthy male subjects (Ss) for seven consecutive nights. Sleep EEG from the baseline night (BLN), the initial drug night (IDN), the fourth and the seventh drug nights (4DN, 7DN) was subjected to fast Fourier transform (FFT) analysis. During NREM sleep of 4DN and 7DN the sigma band (11.0-12.5 Hz) activity was similarly enhanced in every S. In REM of 4DN and 7DN beta band (23.0-29.0 Hz) was enhanced, but with larger variations among Ss. High intra-individual consistency of the relative EEG power patterns on 4DN and 7DN was observed. These results suggest that 1) EEG responses to FNZ are different in sleep states; explorations of these differences may provide better understandings of sleep mechanisms, and 2) individual variations in EEG responses may reflect individual variations of the BDZ receptor system. These methods may be useful for exploring receptor changes in neuropsychiatric disorders.
将4毫克氟硝西泮（FNZ，一种中效苯二氮䓬类催眠药）连续七个晚上口服给予五名健康男性受试者。对基线夜（BLN）、初次用药夜（IDN）、第四次和第七次用药夜（4DN、7DN）的睡眠脑电图进行快速傅里叶变换（FFT）分析。在4DN和7DN的非快速眼动睡眠期间，每个受试者的西格玛频段（11.0 - 12.5赫兹）活动均有类似增强。在4DN和7DN的快速眼动睡眠期，贝塔频段（23.0 - 29.0赫兹）增强，但受试者之间的变化较大。观察到4DN和7DN脑电图相对功率模式的个体内高度一致性。这些结果表明：1）FNZ对脑电图的反应在睡眠状态下有所不同；对这些差异的探索可能有助于更好地理解睡眠机制；2）脑电图反应的个体差异可能反映苯二氮䓬受体系统的个体差异。这些方法可能有助于探索神经精神疾病中的受体变化。
