Manni A, Kleimberg J, Ackerman V, Bellini A, Patalano F, Mattoli S
Institute of Experimental Medicine, Milan, Italy.
Biochem Biophys Res Commun. 1996 Mar 7;220(1):120-4. doi: 10.1006/bbrc.1996.0367.
RANTES is a member of a large supergene family of proinflammatory chemokines that seems to play an important role in inflammatory processes. It is produced by many cell types in response to specific stimuli and during inflammatory reactions, but the marked differences in the pattern of induced expression suggest that different control mechanisms regulate transcription of RANTES in various tissue types. This is supported by the presence of a large number of potential binding sites for transcriptional factors in the promoter region of the RANTES gene. Our data indicate that expression of RANTES mRNA induced by IL-1beta in human lung epithelial cells is associated with the activation of the transcriptional factor NF-kappaB.
调节激活正常T细胞表达和分泌的因子（RANTES）是促炎趋化因子大家族的成员之一，该家族似乎在炎症过程中发挥重要作用。它由许多细胞类型在特定刺激下以及炎症反应期间产生，但诱导表达模式的显著差异表明不同的控制机制调节RANTES在各种组织类型中的转录。RANTES基因启动子区域存在大量转录因子潜在结合位点支持了这一点。我们的数据表明，白细胞介素-1β（IL-1β）诱导人肺上皮细胞中RANTES mRNA的表达与转录因子核因子κB（NF-κB）的激活有关。
