Florence A T, Haq M E, Johnson J R
J Pharm Pharmacol. 1976 Jul;28(7):539-43. doi: 10.1111/j.2042-7158.1976.tb02790.x.
Several physical properties of two polyalkyl alpha-cyanoacrylates relevant to their use in pharmaceutical dosage forms have been investigated. Formation of polymer films at several oil-water interfaces reveals films of diverse morphology. The retardation of solute transfer across an oil-water interface caused by the presence of polymer films formed in situ from the monomers has revealed that the methyl derivative forms the more effective barrier to the test solute, gentian violet. The emulsion-stabilizing properties of the methyl polymer have been studied, and the film-forming properties of the monomers spread from benzene onto water surfaces have been examined using a surface balance.
已对两种聚烷基α-氰基丙烯酸酯在药物剂型中的几种物理性质进行了研究。在几个油水界面形成的聚合物膜呈现出不同的形态。由单体原位形成的聚合物膜导致溶质在油水界面间转移的延迟，这表明甲基衍生物对受试溶质结晶紫形成了更有效的屏障。已研究了甲基聚合物的乳化稳定性能，并使用表面天平研究了从苯扩散到水面上的单体的成膜性能。
