Rollot J M, Couvreur P, Roblot-Treupel L, Puisieux F
J Pharm Sci. 1986 Apr;75(4):361-4. doi: 10.1002/jps.2600750408.
Two different polymerization mechanisms of alkyl cyanoacrylates were compared with regard to their morphological and physico-chemical characteristics. Cyanoacrylates were polymerized by simple emulsification into an aqueous medium or by interfacial polymerization in an o/w type emulsion. Suspensions of particles obtained by these two mechanisms show dramatic differences when studied for their turbidity, refractive index, and stability following centrifugation. These observations are consistent with the fact that nanoparticles obtained by emulsion polymerization are known to be formed by a full polymer core, while nanocapsules obtained by interfacial polymerization were thought to consist of an internal oil droplet surrounded by a polymeric wall. This theory was further confirmed by an electron microscopic examination of the internal structures of the two types of polymeric aggregates.
就其形态和物理化学特性而言，对氰基丙烯酸烷基酯的两种不同聚合机制进行了比较。氰基丙烯酸酯通过简单乳化聚合到水介质中，或通过在油/水型乳液中进行界面聚合。通过这两种机制获得的颗粒悬浮液在研究其浊度、折射率和离心后的稳定性时表现出显著差异。这些观察结果与以下事实一致：已知通过乳液聚合获得的纳米颗粒由完整的聚合物核形成，而通过界面聚合获得的纳米胶囊被认为由被聚合物壁包围的内部油滴组成。通过对两种类型聚合物聚集体的内部结构进行电子显微镜检查，进一步证实了这一理论。
