红花成分烷烃-6,8-二醇对12-O-十四烷酰佛波醇-13-乙酸酯在小鼠皮肤两阶段致癌过程中肿瘤促进作用的抑制效果。

Inhibitory effect of alkane-6,8-diols, the components of safflower, on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.

作者信息

Yasukawa K, Akihisa T, Kasahara Y, Kaminaga T, Kanno H, Kumaki K, Tamura T, Takido M

机构信息

College of Pharmacy, Nihon University, Chiba, Japan.

出版信息

Oncology. 1996 Mar-Apr;53(2):133-6. doi: 10.1159/000227549.

DOI:10.1159/000227549

PMID:8604239

Abstract

Erythro-alkane-6,8-diols were isolated from the flowers of Carthamus tinctorius. 12-0-Tetradecanoylphorbol-13-acetate (TPA, 1 microgram/ear), a tumor-promoting agent, was applied to the ears of mice to induce inflammation. Of 8 alkane-6,8-diols assayed, the C27, C31, C32, C33 and C35 alkane diols inhibited the inflammation. The 50% inhibitory dose of these compounds for TPA-induced inflammation was 0.5-0.7 mg/ear. However, C21, C23 and C25 alkane-6,8-diols were found to have no effect. Furthermore, the mixture of erythro-alkane-6,8-diols from the flowers of C. tinctorius markedly suppressed the promoting effect of TPA on skin tumor formation in mice following initiation with 7,12-dimethylbenz[a]anthracene.

摘要

从红花的花朵中分离出了赤藓烷 - 6,8 - 二醇。将肿瘤促进剂12 - O - 十四烷酰佛波醇 - 13 - 乙酸酯（TPA，1微克/耳）涂抹于小鼠耳部以诱导炎症。在检测的8种烷 - 6,8 - 二醇中，C27、C31、C32、C33和C35烷二醇可抑制炎症。这些化合物对TPA诱导炎症的50%抑制剂量为0.5 - 0.7毫克/耳。然而，发现C21、C23和C25烷 - 6,8 - 二醇没有效果。此外，来自红花花朵的赤藓烷 - 6,8 - 二醇混合物显著抑制了TPA对经7,12 - 二甲基苯并[a]蒽启动后的小鼠皮肤肿瘤形成促进作用。