Wikström M, Wennström J L, Renvert S, Jonsson R
Department of Oral Microbiology, Faculty of Odontology, Göteborg University, Sweden.
Oral Microbiol Immunol. 1996 Feb;11(1):1-7. doi: 10.1111/j.1399-302x.1996.tb00329.x.
In this study, various phenotypes of infiltrating cells in the periodontium adjacent to pockets harboring Porphyromonas gingivalis and Actinobacillus actinomycetemcomitans were evaluated. Furthermore, the pattern of class II antigen expression in the periodontal tissues was determined. Eight lesions were associated with the presence of P. gingivalis and 12 with A. actinomycetemcomitans. Predominant cells in the inflammatory infiltrate were T- and B-cells. In most biopsies T-cells dominated over B-cells. The proportion of P. gingivalis, but not of A. actinomycetemcomitans, was positively correlated to the total number of infiltrating cells in the tissue. A. actinomycetemcomitans sites demonstrated somewhat lower proportions of CD3+, CD4+ and CD19+ cells than P. gingivalis sites. However, the tendency of decreasing CD4+/CD8+ ratio with increasing number of A. actinomycetemcomitans indicates a local imbalance in immunoregulation. The frequency of class II antigen expression of both mononuclear and epithelial cells, a sign of immunological activation, was generally high.
在本研究中，对携带牙龈卟啉单胞菌和伴放线放线杆菌的牙周袋相邻牙周组织中浸润细胞的各种表型进行了评估。此外，还确定了牙周组织中II类抗原的表达模式。8个病变与牙龈卟啉单胞菌的存在有关，12个与伴放线放线杆菌有关。炎症浸润中的主要细胞是T细胞和B细胞。在大多数活检组织中，T细胞比B细胞占优势。牙龈卟啉单胞菌的比例（而非伴放线放线杆菌的比例）与组织中浸润细胞的总数呈正相关。伴放线放线杆菌感染部位的CD3 +、CD4 +和CD19 +细胞比例略低于牙龈卟啉单胞菌感染部位。然而，随着伴放线放线杆菌数量增加，CD4 + / CD8 +比值降低的趋势表明局部免疫调节失衡。作为免疫激活标志的单核细胞和上皮细胞II类抗原表达频率通常较高。
