• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

PCR-SSCP-HDX analysis of pooled DNA for more rapid detection of germline mutations in large genes. The BRCA1 example.

作者信息

Kozłowski P, Sobczak K, Napierała M, Woźniak M, Czarny J, Włodzimierz J, Kryzosiak J

机构信息

Laboratory of Cancer Genetics, Polish Academy of Sciences, Poland.

出版信息

Nucleic Acids Res. 1996 Mar 15;24(6):1177-8. doi: 10.1093/nar/24.6.1177.

DOI:10.1093/nar/24.6.1177
PMID:8604357
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC145751/
Abstract
摘要

相似文献

1
PCR-SSCP-HDX analysis of pooled DNA for more rapid detection of germline mutations in large genes. The BRCA1 example.用于更快速检测大基因种系突变的混合DNA的聚合酶链反应-单链构象多态性-氢/氘交换分析。以BRCA1基因为例。
Nucleic Acids Res. 1996 Mar 15;24(6):1177-8. doi: 10.1093/nar/24.6.1177.
2
Direct genomic multiplex PCR for BRCA1 and application to mutation detection by single-strand conformation and heteroduplex analysis.用于BRCA1的直接基因组多重聚合酶链反应及其在单链构象和异源双链分析中的突变检测应用
Hum Mutat. 2000 Oct;16(4):334-44. doi: 10.1002/1098-1004(200010)16:4<334::AID-HUMU6>3.0.CO;2-6.
3
Combined SSCP/duplex analysis by capillary electrophoresis for more efficient mutation detection.通过毛细管电泳进行联合单链构象多态性/双链分析以更高效地检测突变。
Nucleic Acids Res. 2001 Jul 15;29(14):E71. doi: 10.1093/nar/29.14.e71.
4
Mutation analysis of the BRCA1 gene in 76 Japanese ovarian cancer patients: four germline mutations, but no evidence of somatic mutation.76例日本卵巢癌患者的BRCA1基因突变分析：4例种系突变，但无体细胞突变证据。
Hum Mol Genet. 1995 Oct;4(10):1953-6. doi: 10.1093/hmg/4.10.1953.
5
NF1 mutation analysis using a combined heteroduplex/SSCP approach.使用异源双链/单链构象多态性联合方法进行NF1突变分析。
Hum Mutat. 1997;9(6):548-54. doi: 10.1002/(SICI)1098-1004(1997)9:6<548::AID-HUMU8>3.0.CO;2-Y.
6
Single-strand conformation polymorphism analysis by capillary and microchip electrophoresis: a fast, simple method for detection of common mutations in BRCA1 and BRCA2.通过毛细管电泳和微芯片电泳进行单链构象多态性分析：一种快速、简便的检测BRCA1和BRCA2常见突变的方法。
Genomics. 2000 Jan 1;63(1):25-34. doi: 10.1006/geno.1999.6067.
7
Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer.早发性乳腺癌和卵巢癌家族中BRCA1基因的突变
Nat Genet. 1994 Dec;8(4):387-91. doi: 10.1038/ng1294-387.
8
Heteroduplex and protein truncation analysis of the BRCA1 185delAG mutation.BRCA1基因185delAG突变的异源双链和蛋白质截短分析。
Hum Genet. 1996 Sep;98(3):310-2. doi: 10.1007/s004390050212.
9
Automated detection of prevalent mutations in BRCA1 and BRCA2 genes, using a fluorogenic PCR allelic discrimination assay.
Genet Test. 1997;1(3):171-80. doi: 10.1089/gte.1997.1.171.
10
Mutation analysis of the BRCA1 gene in ovarian cancers.卵巢癌中BRCA1基因的突变分析
Cancer Res. 1995 Jul 15;55(14):2998-3002.

引用本文的文献

1
Mutation Detection in the Tumor Tissue from Selected Polish Patients with Breast Cancer Using Next Generation Sequencing.利用下一代测序技术对选定的波兰乳腺癌患者肿瘤组织进行突变检测。
Genes (Basel). 2021 Apr 2;12(4):519. doi: 10.3390/genes12040519.
2
Development of a Premature Stop Codon-detection method based on a bacterial two-hybrid system.基于细菌双杂交系统的提前终止密码子检测方法的开发
BMC Biotechnol. 2006 Sep 2;6:38. doi: 10.1186/1472-6750-6-38.
3
Combined SSCP/duplex analysis by capillary electrophoresis for more efficient mutation detection.通过毛细管电泳进行联合单链构象多态性/双链分析以更高效地检测突变。
Nucleic Acids Res. 2001 Jul 15;29(14):E71. doi: 10.1093/nar/29.14.e71.

本文引用的文献

1
Faster and cheaper PCR on a standard thermocycler.在标准热循环仪上实现更快、更廉价的聚合酶链式反应。
Acta Biochim Pol. 1995;42(3):363-6.
2
Inherited breast and ovarian cancer.遗传性乳腺癌和卵巢癌。
Hum Mol Genet. 1995;4 Spec No:1811-7. doi: 10.1093/hmg/4.suppl_1.1811.
3
BRCA1 mutations in primary breast and ovarian carcinomas.原发性乳腺癌和卵巢癌中的BRCA1基因突变。
Science. 1994 Oct 7;266(5182):120-2. doi: 10.1126/science.7939630.
4
Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer in ten families.通过分析十个家庭中与乳腺癌和卵巢癌相关的种系突变来确认BRCA1。
Nat Genet. 1994 Dec;8(4):399-404. doi: 10.1038/ng1294-399.
5
Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families.加拿大乳腺癌和卵巢癌家族中BRCA1突变的共同起源。
Nat Genet. 1994 Dec;8(4):392-8. doi: 10.1038/ng1294-392.
6
Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer.早发性乳腺癌和卵巢癌家族中BRCA1基因的突变
Nat Genet. 1994 Dec;8(4):387-91. doi: 10.1038/ng1294-387.
7
A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.一种乳腺癌和卵巢癌易感基因BRCA1的有力候选基因。
Science. 1994 Oct 7;266(5182):66-71. doi: 10.1126/science.7545954.
8
Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction.利用聚合酶链反应快速灵敏地检测点突变和DNA多态性。
Genomics. 1989 Nov;5(4):874-9. doi: 10.1016/0888-7543(89)90129-8.
9
F-SSCP: fluorescence-based polymerase chain reaction-single-strand conformation polymorphism (PCR-SSCP) analysis.F-SSCP：基于荧光的聚合酶链反应-单链构象多态性（PCR-SSCP）分析
PCR Methods Appl. 1992 Aug;2(1):10-3. doi: 10.1101/gr.2.1.10.