Caughey G E, Mantzioris E, Gibson R A, Cleland L G, James M J
Rheumatology Unit, Royal Adelaide Hospital, Australia.
Am J Clin Nutr. 1996 Jan;63(1):116-22. doi: 10.1093/ajcn/63.1.116.
The effect of a flaxseed oil-based diet on tumor necrosis factor alpha (TNF alpha) and interleukin 1 beta (IL-1 beta) synthesis was examined in healthy volunteers. Use of flaxseed oil in domestic food preparation for 4 wk inhibited TNF alpha and IL-1 beta production by approximately 30%. Fish-oil supplementation (9 g/d) continued for a further 4 wk; TNF alpha and IL-1 beta synthesis were inhibited by 74% and 80%, respectively. There was a significant inverse exponential relation between TNF alpha or IL-1 beta synthesis and mononuclear cell content of eicosapentaenoic acid (EPA), an n--3 fatty acid derived from ingested EPA (fish oil) or metabolism of ingested alpha-linolenic acid (flaxseed oil). Cytokine production decreased as cellular EPA increased to approximately 1% of total fatty acids. Further increases in EPA content did not result in further decreases in cytokine production. The results indicate that vegetable oils rich in n--3 fatty acids inhibit TNF alpha and IL-1 beta synthesis.
在健康志愿者中研究了以亚麻籽油为基础的饮食对肿瘤坏死因子α（TNFα）和白细胞介素1β（IL-1β）合成的影响。在家庭烹饪中使用亚麻籽油4周可使TNFα和IL-1β的产生抑制约30%。继续补充鱼油（9克/天）4周；TNFα和IL-1β的合成分别被抑制74%和80%。TNFα或IL-1β的合成与二十碳五烯酸（EPA）的单核细胞含量之间存在显著的负指数关系，EPA是一种n-3脂肪酸，来源于摄入的EPA（鱼油）或摄入的α-亚麻酸（亚麻籽油）的代谢产物。随着细胞内EPA增加到总脂肪酸的约1%，细胞因子的产生减少。EPA含量的进一步增加并未导致细胞因子产生的进一步减少。结果表明，富含n-3脂肪酸的植物油可抑制TNFα和IL-1β的合成。
