Goodman R, Alberman E
Department of Child and Adolescent Psychiatry, Institute of Psychiatry, London, UK.
Dev Med Child Neurol. 1996 Jan;38(1):3-12. doi: 10.1111/j.1469-8749.1996.tb15026.x.
Twins were more than three times more common in a large sample of London children with congenital hemiplegia than in the general population. This over-representation of twins could largely be explained by their higher rate of preterm birth, though twin-specific risk factors, including the consequences of a co-twin's death in utero, may also have played a part. None of the 34 co-twins who survived infancy had hemiplegia or any other form of cerebral palsy. Among 155 siblings of singletons with congenital hemiplegia, no child had hemiplegia and only one had cerebral palsy. Perhaps it is chance rather then genetic liability or an adverse environment that primarily governs who does and does not become congenitally hemiplegic.
在一大群患有先天性偏瘫的伦敦儿童样本中，双胞胎的出现频率是普通人群的三倍多。双胞胎的这种过度代表性在很大程度上可以用他们较高的早产率来解释，不过双胞胎特有的风险因素，包括子宫内同胞双胞胎死亡的后果，可能也起到了一定作用。在34名度过婴儿期的同胞双胞胎中，没有一个患有偏瘫或任何其他形式的脑瘫。在155名单胎先天性偏瘫患者的兄弟姐妹中，没有孩子患有偏瘫，只有一个患有脑瘫。也许主要决定谁会患先天性偏瘫而谁不会患的是偶然因素，而非遗传易感性或不良环境。
