Algaba F
Section of Pathology, Fundació Puigvert, Universitat Autónoma de Barcelona, Spain.
Pathol Res Pract. 1995 Sep;191(9):856-9. doi: 10.1016/S0344-0338(11)80968-4.
The term "premalignant lesion" encompasses diverse morphological entities that vary in their phenotype and biologic behavior. This diversity makes the group heterogeneous, although these lesions share the common factor of having pathologic characteristics intermediate between normal (benign) and neoplastic (malignant). This creates dilemmas in reaching a pathologic diagnosis and in predicting biological behavior. The aim of this article is to present a series of case studies which highlight difficult diagnostic situations. Emphasis is placed on diagnostic criteria and available procedures. At present, two distinct atypical prostatic lesions are recognized: one in which the change is mainly cytological (PIN), and another in which the change is mainly architectural (Atypical adenomatous Hyperplasia or AAH).
“癌前病变”一词涵盖了多种形态学实体，它们在表型和生物学行为上各不相同。尽管这些病变具有介于正常（良性）和肿瘤性（恶性）之间的病理特征这一共同因素，但这种多样性使得该组病变具有异质性。这在做出病理诊断和预测生物学行为方面造成了困境。本文的目的是呈现一系列突出诊断困难情况的病例研究。重点在于诊断标准和可用的检查方法。目前，已识别出两种不同的非典型前列腺病变：一种主要是细胞学改变（前列腺上皮内瘤变，PIN），另一种主要是结构改变（非典型腺瘤样增生，AAH）。
