Eurenius K, Axelsson O, Eriksson L
Department of Obstetrics and Gynecology, Uppsala University, Sweden.
Acta Obstet Gynecol Scand. 1996 Mar;75(3):235-40. doi: 10.3109/00016349609047093.
To estimate the detection rate of abnormal findings, especially fetal anomalies, at second trimester ultrasound screening performed in a way representative of Swedish antenatal clinics.
A prospective study carried out over two years in Uppsala county, Sweden, including 8,228 unselected pregnant women (8,345 fetuses). The ultrasound scans were performed by specially trained midwives.
The number of abnormalities suspected by the midwives and the number of abnormalities confirmed by the obstetricians were registered, as was pregnancy outcome for these cases.
Midwives reported suspected abnormalities at the screening procedure in 59 cases (0.7%), abnormalities were confirmed by obstetricians in 42 cases (0.5%, of which 0.36% were fetal malformations). Seventeen of these 42 pregnancies were terminated and 11 ended with miscarriages or intrauterine fetal deaths. Fourteen of the 42 pregnancies ended with a live born infant, of which two died postnatally.
The described ultrasound screening procedure led to suspected abnormalities in 0.7% of the scanned cases and to confirmed abnormalities in 0.5% of the cases. The outcome for the confirmed abnormalities was poor, as 71% were either terminated or ended with miscarriage or perinatal death.
以瑞典产前诊所具有代表性的方式，评估孕中期超声筛查中异常发现的检出率，尤其是胎儿畸形的检出率。
在瑞典乌普萨拉县进行了一项为期两年的前瞻性研究，纳入8228名未经选择的孕妇（8345例胎儿）。超声扫描由经过专门培训的助产士进行。
记录助产士怀疑的异常数量、产科医生确诊的异常数量以及这些病例的妊娠结局。
助产士在筛查过程中报告了59例怀疑异常（0.7%），产科医生确诊了42例异常（0.5%，其中0.36%为胎儿畸形）。这42例妊娠中有17例终止妊娠，11例以流产或胎儿宫内死亡告终。42例妊娠中有14例分娩活婴，其中2例出生后死亡。
所描述的超声筛查程序在0.7%的扫描病例中发现了怀疑异常，在0.5%的病例中确诊了异常。确诊异常的妊娠结局不佳，71%的病例要么终止妊娠，要么以流产或围产期死亡告终。
