Allessie M A, Konings K, Kirchhof C J, Wijffels M
Department of Physiology, Maastricht University of Limburg, The Netherlands.
Am J Cardiol. 1996 Jan 25;77(3):10A-23A. doi: 10.1016/s0002-9149(97)89114-x.
The presence of an excitable gap during atrial fibrillation (AF), although short and variable, may be of potential importance for the development of alternative techniques for termination of AF by rapid pacing. Also the notion that perpetuation of AF may be partly dependent on macroreentry around the natural atrial orifices, may provide a new therapeutic option for the permanent cure of AF by interrupting the anatomical circular pathways in the atria by radiofrequency ablation. In our opinion the rapidly growing understanding of the electrophysiologic mechanisms of AF certainly warrants some optimism about the possibility of cure of AF in the near future without causing too much discomfort and without carrying on unacceptable risk.
心房颤动（AF）期间可兴奋间隙的存在，尽管短暂且多变，但对于开发通过快速起搏终止AF的替代技术可能具有潜在重要性。此外，AF的持续存在可能部分取决于围绕天然心房口的大折返这一观点，可能为通过射频消融中断心房中的解剖学环形路径来永久治愈AF提供一种新的治疗选择。我们认为，对AF电生理机制的快速深入理解无疑让人对在不久的将来治愈AF的可能性感到乐观，且不会造成太多不适，也不会带来不可接受的风险。
