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60岁以上患者双吻合器回肠储袋肛管吻合术的功能结局

Functional outcome of the double stapled ileoanal reservoir in patients more than 60 years of age.

作者信息

Reissman P, Teoh T A, Weiss E G, Nogueras J J, Wexner S D

机构信息

Department of Colorectal Surgery, Cleveland Clinic Florida, Fort Lauderdale, Florida.

出版信息

Am Surg. 1996 Mar;62(3):178-83.

PMID:8607574
Abstract

Total proctocolectomy with creation of an ileoanal reservoir (IAR) is currently the preferred surgical treatment of mucosal ulcerative colitis and familial adenomatous polyposis. However, the creation of an IAR on older patients is controversial and commonly avoided because of anticipated poor functional results and increased morbidity. We prospectively studied 140 consecutive patients who underwent a double stapled IAR (DSIAR) between 1988 and 1993. We compared the outcome of 14 patients (Group I) 60 years of age or older (mean 65, range 60-71 years; 10 males and 14 females), to 126 patients (Group II) under the age of 60 (mean 37, range 12-59 years; 80 males and 14 females). Mucosal ulcerative colitis and indeterminate colitis were noted, respectively, in 12 (93%) and 1 (7%) patients in Group I and in 94 (75%) and 5 (4%) patients in Group II. In Group II, 21 (16%) patients had familial adenomatous polyposis, and 6 (5%) had a postoperative diagnosis of Crohn's disease. Subjective functional results and anal manometry were assessed in all 14 patients in Group I (100%) and in 110 of the 117 patients in Group II (94%) whose stomas were closed at a mean followup of 24 (3-60) months. Manometry was per- formed before, and 2 and 12 months after surgery. Patients in Groups I and II reported a mean of 6.2 and 5.2 bowel movements during the day (P=NS), and 2 and 1.1 at night, respectively (P<0.05). A total of 12 (86%) patients in Group I and 104 (95%) in Group II reported perfect or almost perfect continence at night (P=NS), and 12 (93%) patients in Group I and 104 (95%) in Group II reported perfect or almost perfect continence during the day (P=NS). The preoperative mean and maximal resting pressures were similar in both groups (71.7 mmHg and 94 mmHG in Group I and 71.6 and 88 mmHg in Group II respectively; P=NS). Postoperative resting pressure changes were also similar in both groups P=NS), with a similar significant decline 2 months after surgery, which recovered by 12 months after surgery in both groups. There were no significant changes between the pre- and postoperative mean and maximal squeeze pressures in either group. The overall morbidity and mortality rates in Groups I and II were 21 and 0 per cent, and 21 and 0.8 per cent, respectively (P=NS). DSIAR in patients 60 years of age or older is as safe and is associated with as good functional and physiologic results as it is in younger patients. Thus, this procedure may be offered to older patients with expectation of good outcome.

摘要

全直肠结肠切除术并回肠肛管储袋(IAR)的构建目前是黏膜溃疡性结肠炎和家族性腺瘤性息肉病的首选手术治疗方法。然而,在老年患者中构建IAR存在争议,并且由于预期功能结果不佳和发病率增加,通常会避免实施。我们前瞻性地研究了1988年至1993年间连续接受双吻合器IAR(DSIAR)手术的140例患者。我们将14例60岁及以上(平均65岁,范围60 - 71岁;10例男性和4例女性)的患者(第一组)与126例60岁以下(平均37岁,范围12 - 59岁;80例男性和46例女性)的患者(第二组)的结果进行了比较。第一组中分别有12例(93%)和1例(7%)患者患有黏膜溃疡性结肠炎和不确定性结肠炎,第二组中分别有94例(75%)和5例(4%)患者患有上述疾病。在第二组中,21例(16%)患者患有家族性腺瘤性息肉病,6例(5%)患者术后被诊断为克罗恩病。对第一组的所有14例患者(100%)以及第二组117例中110例(94%)造口已关闭的患者进行了主观功能结果评估和肛门测压,平均随访时间为24(3 - 60)个月。在手术前、术后2个月和12个月进行测压。第一组和第二组患者白天排便次数平均分别为6.2次和5.2次(P = 无显著性差异),夜间分别为2次和1.1次(P < 0.05)。第一组共有12例(86%)患者和第二组104例(95%)患者报告夜间控便完美或几乎完美(P = 无显著性差异),第一组12例(93%)患者和第二组104例(95%)患者报告白天控便完美或几乎完美(P = 无显著性差异)。两组术前平均静息压力和最大静息压力相似(第一组分别为71.7 mmHg和94 mmHg,第二组分别为71.6和88 mmHg;P = 无显著性差异)。两组术后静息压力变化也相似(P = 无显著性差异),术后2个月均有相似的显著下降,两组在术后12个月均恢复。两组术前和术后平均挤压压力及最大挤压压力均无显著变化。第一组和第二组的总体发病率和死亡率分别为21%和0%,以及21%和0.8%(P = 无显著性差异)。60岁及以上患者的DSIAR与年轻患者一样安全,并且功能和生理结果良好。因此,可以为预期有良好结果的老年患者提供此手术。

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