Fejes-Tóth G, Magyar A, Walter J
Am J Physiol. 1977 May;232(5):F416-23. doi: 10.1152/ajprenal.1977.232.5.F416.
The renal effects of vasopressin (VP) in water-loaded and hydropenic conscious dogs were examined with and without the previous administration of prostaglandin (PG) synthesis inhibitors (indomethacin and meclophenamate). The parameters studied were: urinary output, sodium and potassium excretion, plasma and urinary osmotic concentration, total renal blood flow, mean arterial pressure, heart rate, and the clearance and extraction ratio of p-aminohippuric acid and inulin. The infusion of VP caused antidiuresis and marked saluresis during water diuresis, whereas it was found to be diuretic and saluretic in hydropenic animals. Inhibition of PG synthesis greatly enhanced the antidiuretic activity of VP and abolished its saluretic and diuretic actions. Changes in renal water and solute excretion and changes in the hemodynamic parameters are uncorrelated. It is concluded that intrarenal PGs may play an important role in modulating the renal action of VP.
在有水负荷和缺水的清醒犬中，研究了血管加压素（VP）在给予和未给予前列腺素（PG）合成抑制剂（吲哚美辛和甲氯芬那酸）情况下的肾脏效应。所研究的参数包括：尿量、钠和钾排泄、血浆和尿液渗透浓度、总肾血流量、平均动脉压、心率以及对氨基马尿酸和菊粉的清除率与提取率。在水利尿期间输注VP会引起抗利尿和显著的利钠作用，而在缺水动物中发现其具有利尿和利钠作用。PG合成的抑制极大地增强了VP的抗利尿活性，并消除了其利钠和利尿作用。肾脏水和溶质排泄的变化与血流动力学参数的变化不相关。得出的结论是，肾内PG可能在调节VP的肾脏作用中起重要作用。
