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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

J Physiol. 1982 Jan;322:399-407. doi: 10.1113/jphysiol.1982.sp014044.

Conscious rats received a saline infusion (5.8 ml . hr-1) via a tail vein, for a 6 hr period. For the final 2 hr of this infusion period, prolactin (7.1 microgram (100 g body wt.)-1 . hr-1) was incorporated in the infusate. A control group of animals continued to receive saline alone. 2. In the first hour of prolactin administration (in comparison with the control group), urine flow, sodium output and osmolal output were all significantly reduced (P less than 0.02); there was also a reduction (P less than 0.05) in renal plasma flow (p-amino-hippurate clearance), but the filtration fraction did not alter. The changes in urinary excretion, and in renal haemodynamics, did not persist for the second hour of prolactin administration, but there was a sustained increase in body fluid volume. 3. It is possible that altered renal haemodynamics are responsible for the reduced urinary water and solute excretion which occurs during acute prolactin administration.

清醒大鼠通过尾静脉接受生理盐水输注（5.8毫升·小时⁻¹），持续6小时。在该输注期的最后2小时，将催乳素（7.1微克·（100克体重）⁻¹·小时⁻¹）加入输注液中。一组对照动物继续仅接受生理盐水。2. 在给予催乳素的第一小时（与对照组相比），尿流量、钠排出量和渗透量均显著降低（P<0.02）；肾血浆流量（对氨基马尿酸清除率）也降低（P<0.05），但滤过分数未改变。在给予催乳素的第二小时，尿排泄和肾血流动力学的变化未持续，但体液量持续增加。3. 急性给予催乳素期间出现的尿水和溶质排泄减少可能是肾血流动力学改变所致。

J Physiol. 1982 Jan;322:399-407. doi: 10.1113/jphysiol.1982.sp014044.

Conscious rats received a saline infusion (5.8 ml . hr-1) via a tail vein, for a 6 hr period. For the final 2 hr of this infusion period, prolactin (7.1 microgram (100 g body wt.)-1 . hr-1) was incorporated in the infusate. A control group of animals continued to receive saline alone. 2. In the first hour of prolactin administration (in comparison with the control group), urine flow, sodium output and osmolal output were all significantly reduced (P less than 0.02); there was also a reduction (P less than 0.05) in renal plasma flow (p-amino-hippurate clearance), but the filtration fraction did not alter. The changes in urinary excretion, and in renal haemodynamics, did not persist for the second hour of prolactin administration, but there was a sustained increase in body fluid volume. 3. It is possible that altered renal haemodynamics are responsible for the reduced urinary water and solute excretion which occurs during acute prolactin administration.

清醒大鼠通过尾静脉接受生理盐水输注（5.8毫升·小时⁻¹），持续6小时。在该输注期的最后2小时，将催乳素（7.1微克·（100克体重）⁻¹·小时⁻¹）加入输注液中。一组对照动物继续仅接受生理盐水。2. 在给予催乳素的第一小时（与对照组相比），尿流量、钠排出量和渗透量均显著降低（P<0.02）；肾血浆流量（对氨基马尿酸清除率）也降低（P<0.05），但滤过分数未改变。在给予催乳素的第二小时，尿排泄和肾血流动力学的变化未持续，但体液量持续增加。3. 急性给予催乳素期间出现的尿水和溶质排泄减少可能是肾血流动力学改变所致。