Barbani N, Cascone M G, Giusti P, Lazzeri L, Polacco G, Pizzirani G
Dipartimento di Ingegneria Chimica, Facoltà di Ingegneria, Università degli Studi di Pisa, Italy.
J Biomater Sci Polym Ed. 1995;7(6):471-84. doi: 10.1163/156856295x00544.
Thin films of both pure soluble collagen (CLG) and poly(vinylalcohol) (PVA) and mixtures of the two, ranging from 20-80% PVA composition were studied to test the effects of PVA content and of glutaraldehyde vapour cross-linking. Both the thermal and mechanical behavior and, in addition, proteolytic stability were clearly influenced by the ratio of CLG/PVA. The experimental results indicate that no thermodynamic compatibility occurs between the two homopolymers. However, there is evidence that strong interactions, probably due to hydrogen bond formation, occur between the biological and synthetic polymers. The interactions appear stronger in those films with a lower PVA content and which were not cross-linked. Both the thermal and biological stability are increased and there is an improvement of the mechanical properties. The mutual intermolecular influence appears to allow the attainment of a good mechanical compatibility between CLG and PVA.
对纯可溶性胶原蛋白（CLG）、聚乙烯醇（PVA）以及二者的混合物（PVA含量范围为20%-80%）的薄膜进行了研究，以测试PVA含量和戊二醛蒸汽交联的影响。CLG/PVA的比例对热行为和力学行为以及蛋白水解稳定性均有明显影响。实验结果表明，这两种均聚物之间不存在热力学相容性。然而，有证据表明，生物聚合物和合成聚合物之间可能由于氢键形成而发生强烈相互作用。在PVA含量较低且未交联的薄膜中，这种相互作用似乎更强。热稳定性和生物稳定性均有所提高，力学性能也得到改善。分子间的相互影响似乎使得CLG和PVA之间实现了良好的力学相容性。
