Joos S, Otaño-Joos M I, Ziegler S, Brüderlein S, du Manoir S, Bentz M, Möller P, Lichter P
Deutsches Krebsforschungszentrum, Abt. Organisation komplexer Genome, Heidelberg, Germany.
Blood. 1996 Feb 15;87(4):1571-8.
Primary mediastinal (thymic) B-cell lymphoma is a high-grade non-Hodgkin's lymphoma with unique features. By using comparative genomic hybridization and interphase cytogenetics, 26 tumors were analyzed to identify genomic imbalances. Gains of chromosomal material were much more frequent than losses (110 v 10) and involved chromosomes 9p, 12q, and Xq (31% to 50%). Interestingly, gain of Xq coincided with gain of 9p. Distinct high-level amplifications were found in four subregions. In 2 cases, amplifications of proto-oncogene REL were shown by filter hybridization, indicating a possible pathogenic role of this gene. The characteristic pattern of chromosomal imbalances distinct from other B-cell lymphomas suggests a specific pathway of genetic changes associated with this lymphoma.
原发性纵隔（胸腺）B细胞淋巴瘤是一种具有独特特征的高级别非霍奇金淋巴瘤。通过比较基因组杂交和间期细胞遗传学方法，对26个肿瘤进行分析以确定基因组失衡情况。染色体物质的增加比减少更为常见（110比10），涉及9号染色体短臂、12号染色体长臂和X染色体长臂（31%至50%）。有趣的是，X染色体长臂的增加与9号染色体短臂的增加同时出现。在四个亚区域发现了明显的高水平扩增。在2例病例中，通过滤膜杂交显示原癌基因REL发生扩增，表明该基因可能具有致病作用。与其他B细胞淋巴瘤不同的染色体失衡特征模式提示了与该淋巴瘤相关的特定遗传变化途径。
