Bailly S, Hayem G, Fay M, Kahn M F, Gougerot-Pocidalo M A
Inserm U294, CHU Bichat, Paris, France.
Br J Rheumatol. 1995 Dec;34(12):1123-6. doi: 10.1093/rheumatology/34.12.1123.
Several studies have implicated interleukin 1 alpha (IL-1 alpha) in the pathogenesis of rheumatoid arthritis (RA). We analysed IL-1 alpha intron 6 polymorphism in relation to RA (50 patients with RA and 50 healthy controls). The study of a healthy control population confirmed the existence of the different alleles with a frequency similar to that in the Caucasian populations of northern England. Allele and genotype distributions did not differ significantly between the normal and RA populations, although the allele corresponding to 8 repeats was over-represented in the RA population (8 and 14% in the healthy and RA populations respectively). This suggests that IL-1 alpha intron 6 polymorphism could be part of a complex process involving other unidentified genetic factors in the pathogenesis of RA.
多项研究表明白细胞介素1α（IL-1α）与类风湿性关节炎（RA）的发病机制有关。我们分析了IL-1α内含子6多态性与RA的关系（50例RA患者和50名健康对照者）。对健康对照人群的研究证实了不同等位基因的存在，其频率与英格兰北部白种人群相似。正常人群和RA人群之间的等位基因和基因型分布没有显著差异，尽管对应8个重复序列的等位基因在RA人群中比例过高（健康人群和RA人群中分别为8%和14%）。这表明IL-1α内含子6多态性可能是RA发病机制中涉及其他未确定遗传因素的复杂过程的一部分。
