Tardif J C, Rouleau J L
Research Centre, Montreal Heart Institute, Quebec.
Can J Cardiol. 1996 Apr;12(4):389-98.
Diastolic dysfunction is a syndrome characterized by impaired ventricular filling. Abnormalities in diastolic function can generally be classified as being the result of abnormal relaxation or of abnormal compliance. Diastolic dysfunction is frequently present in patients with heart failure and it is occasionally the dominant or sole cause of symptoms. It is frequently the result of the convergence of factors such as advanced age, renal dysfunction, left ventricular hypertrophy and impaired coronary perfusion. A good history and physical examination are essential for the diagnosis of diastolic dysfunction. Because it uniquely allows for the noninvasive evaluation of mitral and pulmonary venous flow and provides critical information on the cause of diastolic dysfunction and on associated abnormalities, two-dimensional and Doppler echocardiography is the most useful tool in the comprehensive assessment of diastolic function. Treatment of diastolic dysfunction is difficult and should not only focus on controlling symptoms but also include attempts at resolving the underlying cause. Relief of myocardial ischemia, control of arterial hypertension and regression of ventricular hypertrophy are important objectives of treatment.
舒张功能障碍是一种以心室充盈受损为特征的综合征。舒张功能异常通常可分为舒张异常或顺应性异常所致。舒张功能障碍常见于心力衰竭患者，偶尔也是症状的主要或唯一原因。它常是多种因素共同作用的结果，如高龄、肾功能不全、左心室肥厚和冠状动脉灌注受损。详细的病史和体格检查对舒张功能障碍的诊断至关重要。二维和多普勒超声心动图因其能独特地对二尖瓣和肺静脉血流进行无创评估，并提供有关舒张功能障碍病因及相关异常的关键信息，是全面评估舒张功能最有用的工具。舒张功能障碍的治疗困难，不仅应注重控制症状，还应尝试解决潜在病因。缓解心肌缺血、控制动脉高血压和使心室肥厚消退是治疗的重要目标。
