Hou X S, Melnick M B, Perrimon N
Howard Hughes Medical Institute, Harvard Medical School, Boston, Massachusetts 02115, USA.
Cell. 1996 Feb 9;84(3):411-9. doi: 10.1016/s0092-8674(00)81286-6.
We have identified a putative Drosophila STAT protein named Marelle that exhibits mutant phenotypes identical to mutations in the Hopscotch/JAK kinase. We show that a reduction in the amount of marelle gene activity suppresses the phenotype associated with a gain-of-function mutation in hopscotch and enhances the phenotype associated with a weak hopscotch mutation. We propose that Hopscotch activates Marelle to regulate transcription of target genes such as the pair rule gene even-skipped. Our results demonstrate the existence of an invertebrate JAK/STAT system.
我们鉴定出一种名为马雷勒（Marelle）的假定果蝇信号转导和转录激活因子（STAT）蛋白，它表现出与霍普斯科奇/ Janus激酶（JAK）突变相同的突变表型。我们发现，马雷勒基因活性的降低会抑制与霍普斯科奇功能获得性突变相关的表型，并增强与弱霍普斯科奇突变相关的表型。我们提出，霍普斯科奇激活马雷勒以调节靶基因（如实蝇体节极性基因偶数缺口基因）的转录。我们的结果证明了无脊椎动物JAK/STAT系统的存在。
