Conte-Devolx B, Rougon-Rapuzzi G, Millet Y
Ann Endocrinol (Paris). 1977;38(1):61-72.
The authors have developed a radioimmunoassay for human plasma vasopressin (AVP) which permits the estimation of antidiuretic hormon (ADH) levels as low as 0,8 pg/ml. The average plasma level of AVP after overnight water restriction was found to be 14,3 pg/ml (sd = 4,4 pg/ml) in normal subjects. They provoked a hypersecretion of ADH by the intravenous injection of 1-2 mg of nicotine. In 11 volunteer normal subjects this stimulation by nicotine provoked ADH hypersecretion which reached a maximum between 2nd and 15th minutes after injection. In 3 cases of diabetes insipidus, nicotine injection did not induce ADH hypersecretion; in 1 case of potomania this response was weak; in 2 cases of syndrome of inappropriate ADH secretion, AVP plasma levels were elevated and the response after nicotine stimulation was exaggerated.
作者们开发了一种用于检测人血浆血管加压素（AVP）的放射免疫测定法，该方法能够测定低至0.8皮克/毫升的抗利尿激素（ADH）水平。在正常受试者中，过夜禁水后AVP的平均血浆水平为14.3皮克/毫升（标准差=4.4皮克/毫升）。他们通过静脉注射1-2毫克尼古丁来诱发ADH分泌过多。在11名正常志愿者中，尼古丁的这种刺激引发了ADH分泌过多，在注射后第2至15分钟达到最大值。在3例尿崩症患者中，注射尼古丁未诱发ADH分泌过多；在1例水潴留症患者中，这种反应较弱；在2例抗利尿激素分泌不当综合征患者中，AVP血浆水平升高，尼古丁刺激后的反应增强。
