Pereira P, Saldiva P H, Sakae R S, Bohm G M, Martins M A
Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Brazil.
Environ Res. 1995 May;69(2):96-101. doi: 10.1006/enrs.1995.1030.
This study was designed to investigate if animals exposed to urban levels of air pollution develop pulmonary hyperresponsiveness and to test if this change was reversed after moving the animals to a nonpolluted environment. One hundred twenty male Wistar rats were kept in (a) São Paulo (polluted environment) for 3 months (SP3); (b) Atibaia (clean region), for 3 months (A3); (c) São Paulo for 3 months and then Atibaia for a further 3 months (SPA6); (d) Atibaia for 6 months (A6). After the exposure period, the rats were submitted to dose-response curves to inhaled methacholine. Older animals (SPA6 and A6) had lower responses to methacholine in terms of respiratory system resistance when compared to the animals studied after 3 months of experiment (SP3 and A3). However, the response in terms of respiratory system elastance of the SP3 group was significantly (P = 0.0004) greater than those of the other three groups. Our results suggest that the environmental conditions of the large urban centers can induce pulmonary hyperresponsiveness in rats that can be reversed when the animals are removed to a nonpolluted area.
本研究旨在调查暴露于城市空气污染水平的动物是否会出现肺高反应性，并测试将动物转移到无污染环境后这种变化是否会逆转。120只雄性Wistar大鼠被分别饲养在：(a) 圣保罗（污染环境）3个月（SP3）；(b) 阿蒂巴亚（清洁地区）3个月（A3）；(c) 圣保罗3个月，然后在阿蒂巴亚再饲养3个月（SPA6）；(d) 阿蒂巴亚6个月（A6）。在暴露期结束后，对大鼠进行吸入乙酰甲胆碱的剂量反应曲线测试。与实验3个月后研究的动物（SP3和A3）相比，年龄较大的动物（SPA6和A6）在呼吸系统阻力方面对乙酰甲胆碱的反应较低。然而，SP3组在呼吸系统弹性方面的反应显著（P = 0.0004）高于其他三组。我们的结果表明，大城市中心的环境条件可诱导大鼠出现肺高反应性，当动物被转移到无污染地区时，这种反应可逆转。
