RES-1149-1 and -2, novel non-peptidic endothelin type B receptor antagonists produced by Aspergillus sp. I. Taxonomy of producing strain, fermentation, isolation, and physico-chemical and biological properties.
作者信息
Ogawa T, Ando K, Tanaka T, Uosaki Y, Matsuda Y
机构信息
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, Japan.
出版信息
J Antibiot (Tokyo). 1996 Jan;49(1):1-5. doi: 10.7164/antibiotics.49.1.
PMID:8609073
Abstract
RES-1149-1 and -2, novel and non-peptidic endothelin antagonists, were isolated from the cultured broth of a fungus, Aspergillus sp. RE-1149. RES-1149-1 and -2 selectively inhibited the ET-1 binding to endothelin type B receptor (ETB receptor) with IC50 values of 1.5 microM and 20 microM, respectively. Taxonomy of producing strains, fermentation, isolation, and physico-chemical properties of RES-1149-1 and -2 are described.
摘要
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