与四种不同类型白血病相关的转录因子PEBP2/CBF的结构改变。
Structural alterations in the transcription factor PEBP2/CBF linked to four different types of leukemia.
作者信息
Ito Y
机构信息
Department of Viral Oncology, Institute for Virus Research, Kyoto University, Japan.
出版信息
J Cancer Res Clin Oncol. 1996;122(5):266-74. doi: 10.1007/BF01261402.
Abstract
Polyomavirus enhancer binding protein 2 (PEBP2), also called core binding factor (CBF), is a heterodimer composed of the alpha and the beta subunits. Structural alterations of each of the two subunits generated by recurrent chromosome translocations/inversion are associated with acute myeloid leukemia or acute lymphoblastic leukemia. Chimeric proteins containing a part of either the alpha or beta subunits have a potential to affect the transcriptional regulation through the PEBP2/CBF site. Structure and function of PEBP2/CBF and possible mechanisms of leukemogenesis caused by the chimeric proteins are summarized.
摘要
多瘤病毒增强子结合蛋白2（PEBP2），也称为核心结合因子（CBF），是一种由α和β亚基组成的异二聚体。由反复发生的染色体易位/倒位产生的两个亚基中每个亚基的结构改变都与急性髓性白血病或急性淋巴细胞白血病相关。包含α或β亚基一部分的嵌合蛋白有可能通过PEBP2/CBF位点影响转录调控。本文总结了PEBP2/CBF的结构和功能以及由嵌合蛋白引起白血病发生的可能机制。
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