Tanaka R, Okada M, Kajimura N, Otsubo K, Gyotoku M, Nagasaki K, Ekimoto H, Yamaguchi K
Growth Factor Division, National Cancer Center Research Institute, Tokyo, Japan.
Jpn J Clin Oncol. 1996 Apr;26(2):88-94. doi: 10.1093/oxfordjournals.jjco.a023190.
Nude mice bearing the human oral cavity carcinoma cell line OCC-1, and the lung cancer cell line LC-1, developed a triple paraneoplastic syndrome consisting of hypercalcemia, cachexia and leukocytosis. All of these abnormalities disappeared rapidly after surgical resection of the tumors, suggesting their ectopic humoral nature. Search for the factors responsible for the respective abnormalities revealed that the production of parathyroid hormone-related protein and colony-stimulating factors (CSFs), mainly granulocyte-CSF, by the tumors could explain the hypercalcemia and leukocytosis, respectively. With regard to the severe cachexia, the production of two cachexia-associated cytokines, interleukin-6 and leukemia inhibitory factor, was able to explain the syndrome in OCC-1 bearing nude mice; however, the factor responsible in LC-1 bearing nude mice could not be identified. The triple paraneoplastic syndrome that developed in these two animal models could be explained partly by concomitant production of the peptide hormone and cytokines by cancer cells. These animal models may be very useful for the evaluation of diagnostic and therapeutic modalities for humoral abnormalities.
携带人类口腔癌细胞系OCC - 1和肺癌细胞系LC - 1的裸鼠出现了由高钙血症、恶病质和白细胞增多症组成的三联副肿瘤综合征。在肿瘤手术切除后，所有这些异常情况迅速消失，提示它们具有异位体液性质。对导致各自异常情况的因素进行研究发现，肿瘤产生甲状旁腺激素相关蛋白和集落刺激因子（CSF），主要是粒细胞集落刺激因子，可分别解释高钙血症和白细胞增多症。关于严重的恶病质，两种与恶病质相关的细胞因子白细胞介素 - 6和白血病抑制因子的产生能够解释携带OCC - 1的裸鼠中的该综合征；然而，携带LC - 1的裸鼠中导致该综合征的因素尚未确定。在这两种动物模型中出现的三联副肿瘤综合征部分可由癌细胞同时产生肽类激素和细胞因子来解释。这些动物模型可能对评估体液异常的诊断和治疗方法非常有用。
