Staniszewska-Kuś J, Paluch D, Krzemień-Dabrowska A, Zywicka B, Solski L
Zakład Chirurgii Eksperymentalnej i Badania Biomateriałlów Katedra Chirurgii Urazowej Akademii Medycznej, Wrocłlawiu.
Polim Med. 1995;25(3-4):3-18.
Experiments on producing polyurethane membranes which could be used for elements of an artificial heart have been carried out in Poland for several years. In the Institute of Biocybernetics and Biomedical Engineering PAN in Warsaw two kinds of polyurethanes with symbols PU 47 and PU 90 have been worked out. They differ in physicochemical properties and they were subjected to investigations of tissue reaction in the Institute of Experimental Surgery and of Biomaterials Investigations of the Medical Academy in Wrocław. The investigations were carried out on 70 rats of the Wistar breed and on 30 rabbits of the New Zealand breed. Polyurethane circles were implanted into subcutaneous tissue, to peritoneal cavity and into muscles of the back in rats; polyurethane oars were implanted into muscles of the back along the backbone of the rabbits. Sections of the animals were carried out 3, 7, 14, 28, 90 and 180 days after the surgery taking 5 animals in each term. Macroscopic and microscopic as well as physicomechanical investigations were carried out. The carried out experimental investigations of the both kinds of polyurethanes showed good tolerance of the animals' organisms on the implanted material. Summing up, we can say that the tested polyurethane foils with symbols PU 47 and PU 90 satisfy the basic requirements made on the materials designed for temporal contact with a living organism.
在波兰，关于生产可用于人造心脏部件的聚氨酯膜的实验已经进行了数年。在华沙的波兰科学院生物控制论与生物医学工程研究所，已研制出两种分别代号为PU 47和PU 90的聚氨酯。它们的物理化学性质不同，并在弗罗茨瓦夫医科大学实验外科研究所和生物材料研究室接受了组织反应研究。研究在70只Wistar品系大鼠和30只新西兰品系兔子身上进行。将聚氨酯环植入大鼠的皮下组织、腹腔和背部肌肉；将聚氨酯桨状物沿着兔子的脊柱植入背部肌肉。在手术后3、7、14、28、90和180天对动物进行切片，每个时间段取5只动物。进行了宏观、微观以及物理力学研究。对这两种聚氨酯所进行的实验研究表明，动物机体对植入材料具有良好的耐受性。总之，可以说经测试的代号为PU 47和PU 90的聚氨酯箔片满足了对设计用于与生物体进行短期接触的材料的基本要求。
