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[用于修补腹壁的 Dexon、Vicryl 和 Gore-Tex 网片的实验测试]

[Experimental testing of Dexon, Vicryl and Gore-Tex mesh used to complete the abdominal wall].

作者信息

Kateusz J, Misterka S, Staniszewska-Kuś J

机构信息

Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów, Katedra Chirurgii Urazowej Akademii Medycznej we Wrocławiu.

出版信息

Polim Med. 1994;24(3-4):3-39.

PMID:7899175
Abstract

Injuries of abdominal integuments, operations and reoperations of hernias, injuries of a spleen, defects in the wall of the chest and diaphragm cause that the need for substitute materials and alloplastic materials for completing those defects is large. To satisfy this tests have been made experiments with absorbable--Dexon, made by Davis and Geck enterprise, Ethicon and non-absorbable--Teflon made by Gore-Tex enterprise according to the proposition of H. Kuś. The experimental tests were made on 30 rabbits of the white New Zealand breed which weighted 2-3 kg. On the hypogastrium in the distance of 3 cm from the white line on its both sides defects of the size 2 x 3 cm were made. On the right side both fascial-muscular layers of the external and internal oblique muscle of abdomen were cut out but the peritoneum was left while on the left side only one layer was cut out. The defects were completed with nets and fixed with interrupted sutures and then with continuous suture. During the operation the behaviour of the nets in the operation area and the difficulties in connecting the nets with the animals' tissues were tested. Sections of the animals and macroscopic tests were made 7, 14, 21 and 90 days after the implantation of each surgical net estimating the process of healing and resorption of the absorbable nets. The state of the organs of the abdominal cavity was also estimated. Microscopic tests consisted of estimation of the histological specimens made from the tissues taken during the sections of the animals. At the estimation of the surgical convenience of the tested nets it turned out that each of them is very convenient. The differences were in the fact that the Dexon and Vicryl nets had little elasticity and extensibility and after cutting there was a little shredding of their edges. The Gore-Tex net, on the other hand, due to its specific spongy structure, had little extensibility, good elasticity and a complete lack of shredding of the edges after cutting. The macroscopic tests carried out in the planned terms did not showed any deformation or handicap of the functions of the abdominal integuments. The nets implantation did not cause displacement of the internal organs nor intraperitoneal adhesions. On the basis of the microscopic investigation it was noticed that the absorbable surgical nets underwent progressing resorption in the tissues in the period of 21 to 90 days after the implantation.(ABSTRACT TRUNCATED AT 400 WORDS)

摘要

腹部皮肤损伤、疝气手术及再次手术、脾脏损伤、胸壁和膈肌缺损导致用于填补这些缺损的替代材料和异体材料需求量很大。为满足这一需求,根据H. Kuś的提议,已使用可吸收材料——Davis and Geck公司生产的Dexon、Ethicon公司生产的产品,以及不可吸收材料——Gore-Tex公司生产的特氟龙进行了实验。实验在30只体重2 - 3千克的新西兰白兔身上进行。在腹下部距白线两侧3厘米处制造2×3厘米大小的缺损。右侧切除腹外斜肌和腹内斜肌的筋膜肌肉层,但保留腹膜,而左侧仅切除一层。用网片填补缺损,先用间断缝合固定,然后连续缝合。手术过程中测试网片在手术区域的表现以及将网片与动物组织连接的难度。在植入每种手术网片后7天、14天、21天和90天对动物进行解剖和宏观测试,评估可吸收网片的愈合和吸收过程。同时评估腹腔器官的状态。微观测试包括对动物解剖时所取组织制作的组织学标本进行评估。在评估测试网片的手术便利性时发现,它们都非常方便。不同之处在于,Dexon和Vicryl网片弹性和延展性较小,切割后边缘有少量碎屑。另一方面,Gore-Tex网片由于其特殊的海绵状结构,延展性较小,弹性良好,切割后边缘完全没有碎屑。按计划进行的宏观测试未显示腹部皮肤有任何变形或功能障碍。网片植入未导致内脏移位或腹腔内粘连。基于微观研究发现,可吸收手术网片在植入后21至90天内在组织中逐渐被吸收。(摘要截选至400字)

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