Westermark P
Scand J Rheumatol. 1995;24(6):327-9. doi: 10.3109/03009749509095175.
Diagnosis of amyloidosis still relies on tissue biopsy for microscopic examination. Biopsy from a symptom-giving organ may be used but more often an easily available tissue which is affected in most forms of systemic amyloidosis is utilized. Rectal biopsy has its place but a fine needle aspiration biopsy of subcutaneous adipose tissue offers a safe and more convenient alternative. With increasing knowledge about the chemical nature, prognosis and treatment of the different systemic amyloidoses there is an increasing demand of exact chemical typing of amyloid deposits. This typing can be performed immunologically on tissue biopsies, e.g. from subcutaneous adipose tissue, by several different methods. The distribution of amyloid in the body and the therapeutic effects can be monitored by scintigraphy after administration of radiolabelled amyloid P-component.
淀粉样变性的诊断仍依赖于组织活检进行显微镜检查。可以采用有症状器官的活检，但更常用的是在大多数系统性淀粉样变性形式中都会受累的易于获取的组织。直肠活检有其适用之处，但皮下脂肪组织的细针穿刺活检提供了一种更安全、更便捷的替代方法。随着对不同系统性淀粉样变性的化学性质、预后和治疗的了解不断增加，对淀粉样沉积物进行精确化学分型的需求也日益增加。这种分型可以通过几种不同的方法在组织活检（例如来自皮下脂肪组织的活检）上进行免疫检测。在给予放射性标记的淀粉样P成分后，通过闪烁扫描可以监测淀粉样物质在体内的分布和治疗效果。
