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Use of subcutaneous abdominal fat biopsy specimen for detailed typing of amyloid fibril protein-AL by amino acid sequence analysis.利用皮下腹部脂肪活检标本通过氨基酸序列分析对淀粉样纤维蛋白AL进行详细分型。
J Clin Pathol. 1989 Aug;42(8):817-9. doi: 10.1136/jcp.42.8.817.
2
Extended analysis of AL-amyloid protein from abdominal wall subcutaneous fat biopsy: kappa IV immunoglobulin light chain.腹壁皮下脂肪活检中AL淀粉样蛋白的扩展分析：κIV免疫球蛋白轻链
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Use of abdominal fat tissue aspirate in the diagnosis of systemic amyloidosis.腹部脂肪组织抽吸物在系统性淀粉样变性诊断中的应用。
Arch Intern Med. 1983 Aug;143(8):1549-52.
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Proteomic analysis shows that the main constituent of subepidermal localised cutaneous amyloidosis is not galectin-7.蛋白质组学分析表明，皮下局限性皮肤淀粉样变的主要成分不是半乳糖凝集素-7。
Amyloid. 2021 Mar;28(1):35-41. doi: 10.1080/13506129.2020.1811962. Epub 2020 Sep 1.
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Clinical diagnosis and typing of systemic amyloidosis in subcutaneous fat aspirates by mass spectrometry-based proteomics.基于质谱的蛋白质组学对皮下脂肪抽吸物中系统性淀粉样变性的临床诊断与分型
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Amyloidogenic and associated proteins in systemic amyloidosis proteome of adipose tissue.脂肪组织系统性淀粉样变性蛋白质组中的淀粉样蛋白生成及相关蛋白
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本文引用的文献

1
The major proteins of human and monkey amyloid substance: Common properties including unusual N-terminal amino acid sequences.人类和猴子淀粉样物质的主要蛋白质：共同特性，包括不寻常的N端氨基酸序列。
FEBS Lett. 1971 Dec 1;19(2):169-173. doi: 10.1016/0014-5793(71)80506-9.
2
Senile cardiac amyloid is related to prealbumin.老年心脏淀粉样变与前白蛋白有关。
Scand J Immunol. 1980;12(6):503-6. doi: 10.1111/j.1365-3083.1980.tb00098.x.
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Immunocytochemical identification of amyloid in formalin-fixed paraffin sections.福尔马林固定石蜡切片中淀粉样蛋白的免疫细胞化学鉴定
Histochemistry. 1981;72(2):161-71. doi: 10.1007/BF00517130.
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Immunochemical typing of amyloid from tissue biopsies.
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Identification of amyloid prealbumin variant in familial amyloidotic polyneuropathy (Japanese type).家族性淀粉样多神经病（日本型）中淀粉样前白蛋白变异体的鉴定。
Biochem Biophys Res Commun. 1983 Nov 15;116(3):880-8. doi: 10.1016/s0006-291x(83)80224-1.
6
Use of abdominal fat tissue aspirate in the diagnosis of systemic amyloidosis.腹部脂肪组织抽吸物在系统性淀粉样变性诊断中的应用。
Arch Intern Med. 1983 Aug;143(8):1549-52.
7
Structure and antigenic behaviour of kappa I-immunoglobulin light-chain amyloid proteins.
Acta Pathol Microbiol Scand C. 1981 Jun;89(3):199-203. doi: 10.1111/j.1699-0463.1981.tb02686.x.
8
Simple method of diagnostic screening for amyloidosis.淀粉样变性病诊断筛查的简易方法。
Ann Rheum Dis. 1974 Jan;33(1):75-6. doi: 10.1136/ard.33.1.75.
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A new method for the diagnosis of systemic amyloidosis.一种诊断系统性淀粉样变性的新方法。
Arch Intern Med. 1973 Oct;132(4):522-3.
10
Amyloid fibril proteins: proof of homology with immunoglobulin light chains by sequence analyses.淀粉样纤维蛋白：通过序列分析证明与免疫球蛋白轻链的同源性。
Science. 1971 Jun 11;172(3988):1150-1. doi: 10.1126/science.172.3988.1150.

利用皮下腹部脂肪活检标本通过氨基酸序列分析对淀粉样纤维蛋白AL进行详细分型。

Use of subcutaneous abdominal fat biopsy specimen for detailed typing of amyloid fibril protein-AL by amino acid sequence analysis.

作者信息

Westermark P, Benson L, Juul J, Sletten K

机构信息

Department of Pathology, University of Linköping, Sweden.

出版信息

J Clin Pathol. 1989 Aug;42(8):817-9. doi: 10.1136/jcp.42.8.817.

DOI:10.1136/jcp.42.8.817
PMID:2768522
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1142058/
Abstract

A simple technique for the purification of amyloid fibril proteins from patients with systemic amyloidosis was used on a 45 year old woman. The method is based on the use of a surgical subcutaneous fat tissue biopsy specimen which was used for the characterisation of the amyloid as a kappa I AL-protein by amino acid sequence analysis. The method permits the exact typing of amyloid in many patients with systemic amyloidosis, which, until now has been almost exclusively confined to necropsy tissue.

摘要

一种从系统性淀粉样变性患者中纯化淀粉样纤维蛋白的简单技术应用于一名45岁女性。该方法基于使用手术获取的皮下脂肪组织活检标本，通过氨基酸序列分析将淀粉样蛋白鉴定为κI AL蛋白。该方法能对许多系统性淀粉样变性患者的淀粉样蛋白进行准确分型，而在此之前，这几乎完全局限于尸检组织。