Swischuk L E, John S D
Department of Radiology, University of Texas Medical Branch, Galveston 77555-0709, USA.
AJR Am J Roentgenol. 1996 Apr;166(4):917-8. doi: 10.2214/ajr.166.4.8610573.
Since the advent of surfactant therapy for hyaline membrane disease, the problems associated with this condition have been greatly reduced in severity and morbidity. However, many premature infants who recover from the biochemical problem of surfactant deficiency still suffer from structural immaturity of the lungs. This aspect of lung immaturity centers primarily around pulmonary hypoplasia, for these infants, because they are immature, have fewer than normal alveoli and thus cannot accomplish adequate gas exchange. As a result, they are placed on long-term ventilator therapy, which renders them susceptible to problems associated with hypoxia, oxygen toxicity, and barotrauma. Over the last two decades, we have learned a great deal about the pathophysiology of these problems, and we believe that the terminology used to describe them may now be less than accurate. We suggest that the it be adjusted to more correctly reflect the problems seen in these infants.
自从出现用于治疗透明膜病的表面活性剂疗法以来，与这种病症相关的问题在严重程度和发病率方面已大幅降低。然而，许多从表面活性剂缺乏的生化问题中恢复的早产儿仍患有肺部结构不成熟的问题。肺部不成熟的这一方面主要围绕肺发育不全，对于这些婴儿来说，由于他们不成熟，肺泡数量少于正常水平，因此无法完成充分的气体交换。结果，他们需要接受长期通气治疗，这使他们易患与缺氧、氧中毒和气压伤相关的问题。在过去二十年中，我们对这些问题的病理生理学有了很多了解，并且我们认为现在用于描述它们的术语可能不够准确。我们建议对其进行调整，以更准确地反映这些婴儿中出现的问题。
