Konski A A, Domenico D, Irving D, Tyrkus M, Neisler J, Phibbs G, Mah J, Eggleston W
Departments of Radiation Oncology, The Toledo Hospital, Ohio, USA.
Am J Clin Oncol. 1996 Apr;19(2):164-8. doi: 10.1097/00000421-199604000-00015.
DNA flow cytometric content analysis (DFCA) and estrogen (ER) and progesterone (PR) receptor levels are reported to be prognostic with regard to the malignant potential of endometrial adenocarcinoma. We retrospectively reviewed the records of 50 patients presenting with endometrial adenocarcinoma between July 1990 and December 1992, to determine the extent of any pathologic features reported at the time of hysterectomy. Patients whose tumors were nondiploid (aneuploid) by flow cytometry generally presented with a higher pathologic stage, higher grade, and more frequent lymph node involvement. In addition, the majority of clear cell and uterine papillary serous (UPS) adenocarcinoma were also nondiploid. Fourteen of 21 ER-positive tumors aneuploid, as were 18 of 37 PR-positive tumors. We also found DNA-A (DNA content aneuploid) patterns frequently associated with tumor characteristics implicated by other authors as related to aggressiveness. Further studies comparing the molecular biology of tumors to their clinicopathologic features and behavior are needed to fully understand the ultimate malignant potential.
据报道，DNA流式细胞术含量分析（DFCA）以及雌激素（ER）和孕激素（PR）受体水平对于子宫内膜腺癌的恶性潜能具有预后价值。我们回顾性分析了1990年7月至1992年12月期间50例子宫内膜腺癌患者的病历，以确定子宫切除时所报告的任何病理特征的程度。通过流式细胞术检测肿瘤为非二倍体（非整倍体）的患者通常具有更高的病理分期、更高的分级以及更频繁的淋巴结受累情况。此外，大多数透明细胞癌和子宫乳头状浆液性（UPS）腺癌也为非整倍体。21例ER阳性肿瘤中有14例为非整倍体，37例PR阳性肿瘤中有18例为非整倍体。我们还发现DNA-A（DNA含量非整倍体）模式常与其他作者认为与侵袭性相关的肿瘤特征相关。需要进一步研究比较肿瘤的分子生物学与其临床病理特征及行为，以充分了解其最终的恶性潜能。
