Geisinger K R, Homesley H D, Morgan T M, Kute T E, Marshall R B
Cancer. 1986 Oct 1;58(7):1518-25. doi: 10.1002/1097-0142(19861001)58:7<1518::aid-cncr2820580723>3.0.co;2-x.
With endometrial adenocarcinoma, several factors, such as stage and histologic grade, are well recognized as having prognostic significance. Other variables, e.g., nuclear grade, probably are also important clinically. A preliminary investigation of the prognostic value of the ploidy, cell cycle kinetics, and sex steroid receptor contents of these tumors has been conducted and compared with more conventional prognostic factors such as stage, grades, and depth of invasion. As analyzed by flow cytometry, the proliferative activities of the carcinomas were significantly associated with prognosis. Tumors with lower levels of proliferative activity were related to improved survivals. Two thirds of the carcinomas were diploid; ploidy did not carry prognostic weight in the series. Both the estrogen and progesterone receptor status were related to survival. Patients whose tumors were positive for these receptors had a better prognosis than did those in which the receptors were not present in significant quantities.
对于子宫内膜腺癌，诸如分期和组织学分级等几个因素被公认为具有预后意义。其他变量，例如核分级，在临床上可能也很重要。已经对这些肿瘤的倍性、细胞周期动力学和性类固醇受体含量的预后价值进行了初步研究，并与更传统的预后因素如分期、分级和浸润深度进行了比较。通过流式细胞术分析，癌的增殖活性与预后显著相关。增殖活性水平较低的肿瘤与生存率提高有关。三分之二的癌是二倍体；在该系列中倍性不具有预后权重。雌激素和孕激素受体状态均与生存有关。肿瘤这些受体呈阳性的患者比那些受体不存在大量表达的患者预后更好。
