Wu A H, Fontham E T, Reynolds P, Greenberg R S, Buffler P, Liff J, Boyd P, Correa P
School of Medicine, University of Southern California, Norris Comprehensive Cancer Center, Los Angeles, 90033-0800, USA.
Am J Epidemiol. 1996 Mar 15;143(6):535-42. doi: 10.1093/oxfordjournals.aje.a008783.
In a multicenter study of lung cancer in lifetime nonsmokers in the United States, 646 female lung cancer patients and 1,252 population controls were interviewed regarding history of cancer in their first-degree relatives. A 30% increased risk (95% confidence interval 0.9-1.8) was found for a history of respiratory tract cancer in parents or siblings after adjustment for exposure to environmental tobacco smoke (ETS) in adult life. Lung cancer, which represented approximately two thirds of the respiratory tract cancers, occurred more frequently in first-degree relatives of lung cancer patients than in comparable relatives of population controls (ETS-adjusted odds ratio = 1.29, 95% confidence interval 0.9-1.9). In particular, a significant threefold increased risk for lung cancer was associated with lung cancer diagnosed in mothers and sisters. The increased risk in relation to family history of lung cancer was observed among parents and siblings who were smokers as well as in those who were nonsmokers. The association with family history of lung cancer was strengthened when the analysis was restricted to adenocarcinoma of the lung (ETS-adjusted odds ratio = 1.50, 95% confidence interval 1.0-2.2). However, there was no association between family history of other cancers and risk of lung cancer in nonsmokers.
在美国一项针对终生不吸烟者肺癌的多中心研究中，对646名女性肺癌患者和1252名人群对照者就其一级亲属的癌症病史进行了访谈。在对成年期接触环境烟草烟雾（ETS）进行调整后，发现父母或兄弟姐妹有呼吸道癌症病史的人群患癌风险增加了30%（95%置信区间为0.9 - 1.8）。肺癌约占呼吸道癌症的三分之二，在肺癌患者的一级亲属中比在人群对照者的类似亲属中更频繁发生（经ETS调整后的优势比 = 1.29，95%置信区间为0.9 - 1.9）。特别是，母亲和姐妹被诊断为肺癌会使患肺癌的风险显著增加三倍。在吸烟的父母和兄弟姐妹以及不吸烟的父母和兄弟姐妹中，均观察到与肺癌家族史相关的风险增加。当分析仅限于肺腺癌时，与肺癌家族史的关联得到加强（经ETS调整后的优势比 = 1.50，95%置信区间为1.0 - 2.2）。然而，在不吸烟者中，其他癌症的家族史与肺癌风险之间没有关联。
