Lund P C, Cwik J C, Gannon R T, Vassallo H G
Br J Anaesth. 1977 May;49(5):457-60. doi: 10.1093/bja/49.5.457.
The effectiveness and safety of etidocaine during extradural anaesthesia for Caesarean section were evaluated in 81 patients. Adequate sensory analgesia occurred in 78 patients and muscle relaxation was excellent in all patients. The combined umbilical venous-umbilical arterial/maternal venous ratio was 0.28+/-0.2 following the administration of 1% etidocaine 25 ml with adrenaline and 0.38+/-0.2 following the administration of 1% etidocaine plain 25 ml. Neurobehavioural patterns of the newborn were not affected noticeably. Etidocaine, in appropriate dose and concentration, appears to be an excellent local anaesthetic agent for Caesarean section under extradural anaesthesia.
对81例剖宫产硬膜外麻醉期间依替卡因的有效性和安全性进行了评估。78例患者出现了充分的感觉镇痛,所有患者的肌肉松弛效果均极佳。给予含肾上腺素的1%依替卡因25ml后,脐静脉-脐动脉/母体静脉联合比率为0.28±0.2,给予单纯1%依替卡因25ml后,该比率为0.38±0.2。新生儿的神经行为模式未受到明显影响。在适当的剂量和浓度下,依替卡因似乎是剖宫产硬膜外麻醉的一种极佳局部麻醉剂。