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本文引用的文献

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Amino acid metabolism in mammalian cell cultures.哺乳动物细胞培养中的氨基酸代谢
Science. 1959 Aug 21;130(3373):432-7. doi: 10.1126/science.130.3373.432.
2
Expression of glutathione S-transferase P-form in primary cultured rat liver parenchymal cells by coplanar polychlorinated biphenyl congeners is suppressed by protein kinase inhibitors and dexamethasone.
FEBS Lett. 1993 Oct 25;333(1-2):114-8. doi: 10.1016/0014-5793(93)80386-9.
3
The stress-activated protein kinase subfamily of c-Jun kinases.c-Jun激酶的应激激活蛋白激酶亚家族。
Nature. 1994 May 12;369(6476):156-60. doi: 10.1038/369156a0.
4
How important is the protein phosphorylation pathway in the toxic expression of dioxin-type chemicals?蛋白质磷酸化途径在二噁英类化学物质的毒性表达中有多重要？
Biochem Pharmacol. 1994 Jul 19;48(2):215-24. doi: 10.1016/0006-2952(94)90089-2.
5
Tumor necrosis factor alpha stimulates AP-1 activity through prolonged activation of the c-Jun kinase.肿瘤坏死因子α通过持续激活c-Jun激酶来刺激AP-1活性。
J Biol Chem. 1994 Oct 21;269(42):26396-401.
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Polychlorinated biphenyls (PCBs), dibenzo-p-dioxins (PCDDs), and dibenzofurans (PCDFs) as antiestrogens in MCF-7 human breast cancer cells: quantitative structure-activity relationships.多氯联苯（PCBs）、二苯并对二恶英（PCDDs）和二苯并呋喃（PCDFs）作为MCF-7人乳腺癌细胞中的抗雌激素：定量构效关系
Toxicol Appl Pharmacol. 1993 May;120(1):55-61. doi: 10.1006/taap.1993.1086.
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Acute 2,3,7,8-tetrachlorodibenzo-p-dioxin exposure results in enhanced tyrosylphosphorylation and expression of murine hepatic cyclin dependent kinases.急性2,3,7,8-四氯二苯并对二恶英暴露导致小鼠肝脏细胞周期蛋白依赖性激酶的酪氨酸磷酸化增强和表达增加。
Biochem Biophys Res Commun. 1993 Dec 30;197(3):1070-7. doi: 10.1006/bbrc.1993.2587.
8
The placental form of glutathione S-transferase as a new marker protein for preneoplasia in rat chemical hepatocarcinogenesis.谷胱甘肽S-转移酶的胎盘形式作为大鼠化学性肝癌发生过程中癌前病变的一种新的标记蛋白。
Gan. 1984 Mar;75(3):199-202.
9
Immunochemical quantitation of cytochrome P-450 isozymes and epoxide hydrolase in liver microsomes from polychlorinated or polybrominated biphenyl-treated rats. A study of structure-activity relationships.多氯联苯或多溴联苯处理大鼠肝脏微粒体中细胞色素P-450同工酶和环氧化物水解酶的免疫化学定量分析。结构-活性关系研究。
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Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.

一种共面多氯联苯刺激原代培养大鼠肝实质细胞中c-Jun的磷酸化。

Phosphorylation of c-Jun stimulated in primary cultured rat liver parenchymal cells by a coplanar polychlorinated biphenyl.

作者信息

Tanno K, Aoki Y

机构信息

National Institute for Environmental Studies, Ibaraki, Japan.

出版信息

Biochem J. 1996 Feb 1;313 ( Pt 3)(Pt 3):863-6. doi: 10.1042/bj3130863.

DOI:10.1042/bj3130863
PMID:8611167
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1216990/
Abstract

Phosphorylation of c-Jun was stimulated in primary cultured rat liver parenchymal cells by treatment with a coplanar polychlorinated biphenyl congener, 3,3'4,4'5-pentachlorobiphenyl (PenCB), as well as by epidermal growth factor, but was not stimulated by the non-coplanar form. However, the amount of c-Jun mRNA did not increase with PenCB treatment. PenCB may activate a signal-transducing pathway consisting of protein kinases.

摘要

在原代培养的大鼠肝实质细胞中，共平面多氯联苯同系物3,3',4,4',5-五氯联苯（PenCB）以及表皮生长因子可刺激c-Jun的磷酸化，但非共平面形式则无此作用。然而，PenCB处理并未使c-Jun mRNA的量增加。PenCB可能激活了一条由蛋白激酶组成的信号转导途径。